The mutant shapeshifter known as Mystique has been many things in her lengthy career that has ranged from covert spy to mutant terrorist to government operative to a member of the X-Men and back again, working the character into the history of the Marvel universe while also making her a prime candidate for appearances outside of the comics.
Mystique is one of the few characters to have appeared in almost every single live-action and animated adaptation of the X-Men and has even appeared in other Marvel animated series that further showcased her wide range as a villain. Of course, while Mystique has many appearances in other mediums, some of those adaptations have strayed far from the comic character.
12 The Super Hero Squad Show (2009)
Mystique appeared alongside the rest of Marvel's villains in The Super Hero Squad Show, which was a kid-friendly cartoon that had a huge cast of characters that were fairly loosely based on the comic versions of the characters.
Mystique was voiced by Game of Thrones' Lena Headey as a member of Doctor Doom's Lethal Legion which gave the character a British accent for the first time in her non-comic appearances, though the youthful nature of the series didn't give Mystique much room to flex.
11 X-Men: The Last Stand (2006)
Rebecca Romijn brought the character of Raven Darkholme/Mystique to life in a brand new way during the first live-action trilogy of the X-Men, though her final appearance as the character in 2006's X-Men: The Last Stand was underwhelming.
As Magneto assembled a new Brotherhood of Evil Mutants, Mystique was shot with the mutant cure, losing her powers and causing Magneto to leave her behind. This led to the now human Raven's betrayal of her former partner, which was fairly out-of-character for the cinematic Mystique.
10 X-Men: Dark Phoenix (2019)
The final film in Fox's cinematic X-Men franchise was 2019's X-Men: Dark Phoenix, which starred the younger team that formed during the second trilogy as they dealt with a new take on the iconic "Dark Phoenix Saga" storyline from the comics.
Jennifer Lawrence's final outing as Mystique didn't go well for the character as she was unceremoniously killed off by Jean Grey during a Phoenix episode, further confusing the already messy timeline of the cinematic X-Men while sending Mystique off with a whimper instead of a bang.
9 Marvel Disk Wars: The Avengers (2014)
Marvel Disk Wars: The Avengers put the power of Earth's mightiest heroes into the hands of a group of children in the 2014 anime series that trapped a number of heroes and villains in high-tech identity disks.
Mystique (voiced by Masumi Asano) appeared in "A Brand New Red Terror!" as one of Red Skull's hired mercenaries attempting to collect the identity disks, though she was betrayed and almost killed by Crossbones before she was saved by the arrival of Sunfire.
8 X-Men: Apocalypse (2016)
2016's X-Men: Apocalypse returned Jennifer Lawrence's Mystique to a new version of the X-Men that formed during the 80s in order to combat the growing threat of Apocalypse and his powerful mutant Horsemen.
Mystique's status as a mutant freedom fighter after the previous films helped to inspire a new class of X-Men as the character comes to terms with her place among mutants and accepts her role as a leader of the X-Men, with the film giving Mystique one of her best film costumes in the climax as she officially takes command.
7 X-Men: First Class (2011)
When the X-Men franchise was rebooted to explore the early days of the mutant team in 2011's X-Men: First Class, Jennifer Lawrence took on the role of a younger Raven Darkholme/Mystique and her origins were greatly altered from the comics.
Mystique now became Charles Xavier's adoptive sister (Morgan Lily played young Raven) and was an integral part of the development of the X-Men, becoming one of the team's first members that began to lay the seeds for her eventual alliance with Magneto that featured in the original cinematic trilogy.
6 Wolverine And The X-Men (2009)
Mystique (voiced by Tamara Bernier) appeared on 2009's Wolverine And The X-Men in a number of episodes that established her mysterious (and romantic) past with Wolverine alongside the rest of Team X that included Sabretooth and Maverick.
This take on the character wore a modified version of her classic white outfit and expertly used her shape-shifting abilities to infiltrate the X-Men and government bases while also forming her own Brotherhood, though the series was canceled before she was able to be explored further.
5 X-Men: Days of Future Past (2014)
Jennifer Lawrence was given the chance to shine in the role of Mystique for 2014's X-Men: Days of Future Past, which further evolved the character from her role as one of Xavier's students into a powerful operative fighting against a dark future for mutantkind.
Mystique used her shape-changing abilities to gather information, infiltrate the highest levels of government security, and almost potentially assassinate the president as the catalyst of the very future she was trying to prevent, though the film also set her on a new heroic path that again divulged from her comic origins.
4 X-Men: The Animated Series (1992)
The X-Men reached new mainstream levels of popularity in the 90s thanks to X-Men: The Animated Series, which featured a wide selection of mutant heroes and villains over the course of five seasons on Fox Kids.
Mystique (voiced by Randall Carpenter and Jennifer Dale) initially appeared as a disciple of Apocalypse that first teased her connection to Rogue as her adoptive mother, though it would also further explore the interesting familial relationship between her, Nightcrawler, Sabretooth and Graydon Creed.
3 X-Men (2000)
When the 2000's X-Men hit the big screen, Magneto was accompanied by a small roster of his Brotherhood of Mutants that included a very unique take on Mystique, played by Rebecca Romijn in the first of many appearances in Fox's X-franchise.
Mystique's shape-changing mutant abilities became more visually represented in her live-action portrayal as her body was covered by transformative scales that replaced her typical comic costume. Mystique's abilities and her dynamic fighting style made her a standout member of the Brotherhood.
2 X2: X-Men United (2003)
Romijn returned to the role of Mystique in 2003's X2: X-Men United as the only returning member of Magneto's Brotherhood as they were forced to unite with the X-Men in order to stop the plans of Colonel William Stryker.
Mystique further displayed her unique abilities to infiltrate the highest places of security while also humiliating squads of soldiers that solidified Mystique as an extreme threat in the X-Men's cinematic universe that was an unfortunate peak for the original trilogy's version of the character.
1 X-Men: Evolution (2000)
Kid's WB! reimagined the X-Men and the Brotherhood as high school students in 2000's X-Men: Evolution, and as Professor Xavier guided his team of young X-Men, the Brotherhood soon found a mentor as well.
Mystique (voiced by Colleen Wheeler) led the Brotherhood on behalf of Magneto, who further enhanced the character to resemble her live-action scaled appearance. Mystique's relationship with Rogue and Nightcrawler was well-developed and she was even transformed into a Horsemen of Apocalypse alongside powerful mutants like Magneto, Storm and Xavier.