Woody Harrelson is Wilson in Trailer For Daniel Clowes Adaptation

Woody Harrelson and Laura Dern star in the red-band trailer for "Wilson," based on the 2010 graphic novel by Daniel Clowes.

RELATED: Film Adaptation of Daniel Clowes' "Wilson" Lands Release Date

The film explores the life of lonely, neurotic middle-aged misanthrope (Harrelson) who discovers he has a daughter named Claire (Isabella Amara), who was given up for adoption by his ex-wife (Laura Dern) shortly after the couple divorced. The revelation that he is actually a father leads to inept attempts by Wilson to reconnect with his ex-wife and the daughter he never knew he had.

As with the two previous films based on his work, "Ghostworld" (2001) and "Art School Confidential" (2006), "Wilson's" screenplay was written by Clowes himself, ensuring the cartoonist retains some measure of control.

RELATED: Daniel Clowes Returns With "Patience," a "Psychedelic Sci-Fi Love Story"

The adaptation was originally to be directed by Alexander Payne ("Sideways"), but he instead stepped into a producer role and was replaced behind the camera by Craig Johnson ("Skeleton Twins").

Judging from the trailer, Clowes' script retains all of the social awkwardness that is a hallmark of his work, in addition to lashings of ribald humor.

Also starring Judy Greer, Cheryl Hines and Isabella Amara, “Wilson” opens March 24, 2017, from Fox Searchlight.

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