In his early years, M.O.D.O.K. was consistently a thorn in the side of the Incredible Hulk, which led to the creation of the supervillain Harpy, who is actually a mutated Betty Ross (then going by Betty Talbot due to her having married Glenn Talbot). After Glenn seemingly dies, Betty is left in a bad way, which M.O.D.O.K. uses to his advantage, calling her to a secret facility where he bombards her with gamma radiation, turning her into a scaly green monster with wings. M.O.D.O.K. dubs the creature Harpy (he really likes naming his monstrosities).
The story, which can be found in Incredible Hulk #168, recalls Kate Bishop's more recent predicament, as there are several allusions to the older issue in West Coast Avengers #3. For instance, the gamma radiation M.O.D.O.K. bombards Betty with produces a similar effect to the gun B.R.O.D.O.K. uses to stun Kate. Additionally, the device B.R.O.D.O.K. uses to transform Kate into a giant hawk bears a striking resemblance to the one that transforms Betty. Of course, there's no looking past the fact that Kate is turned into a hawk, while Betty is turned into a ferocious monster with scales and wings, both capable of flight and both looking equally pissed.
Perhaps one of the most memorable victims of M.O.D.O.K.'s biological meddling is Katherine Waynesboro, a S.H.I.E.L.D. agent tasked with secretly keeping an eye on Bruce Banner. As is often the case, Katherine's cover gets blown quick, which leads to her getting abducted by one of Hulk's greatest nemeses, the Abomination. In Incredible Hulk #290, the Abomination brings Katherine back to an A.I.M. facility, where the minions of M.O.D.O.K., enjoying a brief moment of respite while their leader and tormenter is exiled, immediately decide Katherine is a prime candidate to become the new M.O.D.O.K.
The mad scientists throw her into a strange machine and she returns more terrifying than ever, bearing the name Ms. M.O.D.O.K. Hulk, M.O.D.O.K. and Ms. M.O.D.O.K. all throw down, with the end result being a massive explosion that wrecks the facility but turns Katherine back into her human form. It's not exactly M.O.D.O.K. turning a defenseless woman into a monster, as the act is perpetrated by A.I.M. scientists, but it is a curious example of the villain's disciples turning yet another Kate into a twisted version of herself.