WATCH: The 'Powerpuff Girls' Are Back in Action in the First Clip from the New Series

In the first clip from Cartoon Network's new "Powerpuff Girls" series, Buttercup teaches Manboy -- a foe who "has vowed to turn the city of Townsville into the city of Mansville" -- a lesson after he calls her "princess."

Created by Craig McCracken, “The Powerpuff Girls” originally aired from 1998 to 2004, and chronicled the adventures of three super-powered girls created by scientist Professor Utonium. The 78-episode run also inspired a 2003 feature film, a 10th-anniversary special and, last year, the reimagined CG-animated special.

The new series will look much like the original — as opposed to the 2014 “Powerpuff Girls Special: Dance Pantsed.” However, the voice cast is mostly new, featuring Amanda Leighton (“The Fosters”) as Blossom, Kristen Li as Bubbles and Natalie Palamides as Buttercup, with series veteran Tom Kenny reprising his role as the Narrator/Mayor.

The new series, which debuts in April, is executive produced by Nick Jennings (“Adventure Time”) and co-executive produced by “Wow! Wow! Wubbzy!” creator Bob Boyle.

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