Oscar winner Eddie Redmayne stars as Lili Elbe, one of the first known recipients of sexual-reassignment surgery, in the first trailer for "The Danish Girl."

Set in 1920s Copenhagen, director Tom Hooper's biographical drama tells the true story painter of Einar Wegener -- later Lili Elbe -- who after helping his wife Gerda Wegener (Alicia Vikander) complete a painting by posing with a dress, begins a long journey of self-discovery.

Opening Nov. 27 in limited release, "The Danish Girl" also stars Matthias Schoenaerts, Ben Whishaw and Amber Heard.