Wade Wilson, better known as Deadpool, loves getting involved with monsters. For a while, he was married to Shiklah, the queen of the monsters and he currently rules as king over the monsters in New Jersey. All of this makes his various run-ins with the symbiote alien monster goo no surprise, and that includes being taken over by Venom's symbiote.
The special What If Venom Possessed Deadpool? by Rick Remender, Shawn Moll, Mark Irwin, John Livesay, Walden Wong, Scott Hanna, and Chris Sotomayor, took the bonding a step further. Published in 2010, the story started in 1985 when Deadpool was hired by Galactus to kill the Beyonder, because the Beyonder had merged M.O.D.O.K. to Galactus's rear end, which did not sit too well with the villain. Giving Deadpool the Retcon Expungifier, a weapon that can change anyone's reality, Galactus sent him after the Beyonder.
Deadpool tracked down the Beyonder to a club but decided not to kill him. Instead, Deadpool fell under the Beyonder's sway and became his friend. Wearing the infamous black suit, Spider-Man crashed into their endless partying. While Spider-Man argued with the Beyonder about the suit, a piece of the symbiote came off and merged with Deadpool, creating the Jheri-curled Venompool. He and the Beyonder party for ten years, until the Beyonder grew bored with Venompool and abandoned both him and Tony Stark. Seizing the moment, Venompool sold Tony Stark to A.I.M. and used the money to get clean and start a new life. But when he tried to become a hero, none of the teams, except for the Defenders, would take him because of his hairstyle.
Desperate to be free of the dated curly style, Venompool went to a bell tower to rid himself of the symbiote. Free of it, Venompool now thought he could become a true hero. He tried but instead of being viewed as heroic, he horrified people with his mindless violence, such as ripping a purse-snatcher in half. Still feeling unnoticed, Venompool tried to battle in "Secret Wars" but found it all silly and pointless.
In a late '90s-type talk show reveal, Venompool revealed how the symbiote hair became his arch-nemesis named Carnage Curl. Throughout the years she has ruined his life by killing his secret uncle and messing with his plumbing. All the while she was dating the Beyonder and keeping Venompool from killing him. Carnage Curl shocked everyone by saying that she was pregnant with Galactus's baby. Which led to the two enemies destroying the earth. Using the Retcon Expungifier, Venompool blasted both characters from all continuity and restored the world with him as the hero.
Now that Venompool had the world's adoration, it still wasn't enough. Soon he realized that sharing the spotlight with other heroes was not something he wanted to do. To solve this problem Venompool killed every hero, and villain -- anyone capable of outshining him. Of course, he didn't deal with success well, with the power going to his head and still feeling like a victim in the story.
In the end, Venompool understood that he had focused on the wrong things in life. Instead of building an existence of meaning and having deep relationships, everything he had was vapid and superficial. So he went home and pulled out the Retcon Expungifier to fix his mistakes. Where most would expect the regretful anti-hero to erase himself, Venompool kept true to his selfish nature and just erased the entire Earth-615.9 universe. Perhaps this was the best way to fix the insane timeline that created both a soulless Deadpool and an aimless Venom.