Damiano, 19, was nominated for a 2009 Tony Award for best featured actress in a musical for her role in Next to Normal. She's also appeared in an episode of Gossip Girl.
She'll join 26-year-old newcomer Reeve Carney in a $52-million production directed by The Lion King's Julie Taymor and scored by U2's Bono and the Edge. Spider-Man is finally set to open in November after months of delays led to the departures of Wood in March and Alan Cumming in April. There's been no announcement as to who will replace Cumming as Green Goblin.
Spider-Man, possibly the most expensive musical in Broadway history, will cost about $1 million a week to produce -- hundreds of thousands of dollars more than elaborate shows like Mary Poppins and West Side Story -- and require the 1,700-seat Hilton Theatre in New York City to sell out for every show for four years just to break even.