Lisa Simpson from The Simpsons has long been the most openly musical of her family, with her saxophone providing her a great deal of comfort over the years. Those musical skills even extend to the distant future of Futurama, where her musical prowess ended up actually impacting the entire planet.

Lisa Simpson is such a good musician that, when she encountered the Holophoner from Futurama, she mastered it within hours and used it to help save the world.

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The Holophoner was introduced in the third season of Futurama. A fusion of a typical woodwind instrument and a holographic projector, the Holophoner is a famously impressive instrument. By playing the instrument, the user can create holograms to further express the meaning and intention of their music. When it's first introduced, it's established that utilizing the instrument is an inherently difficult task -- with Leela claiming there's only one genuine master with it. While some have been shown playing it decently, this suggests how difficult of a practice it is to master.

In the Season 3 episode "Parasites Lost," a mentally enhanced Fry proves capable of playing the Holophonor, quickly winning Leela's heart and attention with the musical creations he produces. However, he is later forced to expel the worms from his body or risk them becoming a permanent element of his body. Fry would try to master the Holophoner again in Season 4's "The Devil's Hands Are Idle Playthings," taking classes but failing to perfect the instrument. Winning a wager with the Robot Devil, Fry gains his robotic hands and a mastery of the instrument, becoming a world-famous musician and even penning an opera about Leela.

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However, there's one character who showcased a quick skill with the instrument: Lisa Simpson. In The Simpsons Season 26 episode "Simpsorama," the Simpsons interact with the characters from Futurama when they travel back to their relative past. Monstrous radioactive versions of Bart -- produced by a sample of his DNA and radiation from the Nuclear Power Plant gestating for a thousand years -- have ravaged the Futurama time-period, forcing the Planet Express crew to investigate. However, the device keeping them in the past is damaged, dragging them -- and Homer, Marge, Bart and Lisa -- into the future.

There, Lisa is able to use her years of experience dealing with Bart to trick the legions of Bart creatures. This includes aggravating them with a saxophone-variant of the Holophoner. Even just taking the instrument into her hands for the first time, Lisa is quickly able to figure out the instrument, producing a soft song that creates cutesy holograms of ponies and flowers. Lisa uses this to force all the Bart copies into a single building, allowing the Planet Express crew to drag it into space and off-world. While it's an understated moment, Lisa quickly picking up the Holophoner speaks to just how innately talented Lisa really is with music. She was able to master a supposedly impossible instrument within a day of knowing it existed, and then helped save the entire planet with it.

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