WARNING: The following contains spoilers for The Flash #758, by Joshua Williamson, Christian Duce, Scott Kolins, Luis Guerrero, Hi-Fi and Steve Wands, available now.
One event more than any other has loomed heavily on Barry Allen long before he gained superpowers and took on the mantle of the Flash: The brutal murder of his mother Nora Allen. While Barry was a boy, a time-traveling Reverse-Flash went back in time to rewrite history by killing Nora and framing Barry's father Henry Allen for the crime, resulting in years of imprisonment. The traumatic loss served as Barry's primary motivation for joining the Central City Police Department as a forensic scientist, using his expertise and free time to investigate his mother's case to find enough evidence to clear his father's name and secure a release from prison.
Another element of the Allen family history has resurfaced from the far-future in the Tornado Twins, Barry and Iris West-Allen's children born in the 31st century. Before Barry could be a part of his children's lives, he was kidnapped by the Anti-Monitor to power the omnipotent villain's antimatter cannon during Crisis on Infinite Earths, resulting in Barry's heroic sacrifice to destroy the multiverse-killing weapon. Without their parents' moral upbringing, Don and Dawn Allen grew up to become fearsome supervillains who were raised in the DC Universe's future to hate their father by Barry's own longtime nemesis Eobard Thawne, the Reverse-Flash.
In The Flash #758, Barry's present and future violently collide with one another as Thawne recruits the Tornado Twins into his antagonistic ensemble, the Legion of Zoom. The Reverse-Flash and Tornado Twins were conspicuously absent during the Legion's opening assault, as Barry scrambled to contend with simultaneous attacks committed by the Turtle, Gorilla Grodd, the Trickster, Captain Cold and Golden Glider. Realizing that Thawne would likely return to the scene of the most heinous crime he committed all those years ago, Barry returns to his childhood home only to have the Tornado Twins finally make their explosive entrance.
Ambushing their father, Don and Dawn overpower the Scarlet Speedster while completely destroying the home he grew up in around them.
In a flash of murderous light, Barry Allen's entire life had changed in that old house in the suburbs of Central City. His happy childhood was completely upended by the Reverse-Flash meddling with his nemesis' history, completely rupturing the Allen family and setting Barry on a course to become an obsessive police scientist long before he became a superhero. Thawne's impact on the Allens would go on to become generational, serving as a twisted father figure to Barry's time-displaced children and raising them in his own villainous image while fostering their hatred against their parents. And with the combined might of the Legion of Zoom attacking him, Barry's legacy against the Reverse-Flash comes careening around him in the wreckage of where their longstanding animosity began.
As the Legion of Zoom converges around him, Barry Allen's past, present and future have similarly all come together in the nexus that is his childhood home, the site of where his entire life was forever altered. Outnumbered by his greatest enemies, Barry has been handed one of his worst defeats of all time, with the orchestrator of all his major tragedies and his own children helping bring about his downfall. And while Barry's running long odds of being able to snatch a victory from the jaws of looming defeat, the Scarlet Speedster has pulled out unlikely wins before, but he'll have to run like hell just to keep up with Thawne's plans.