After Season 5 of The Flash ended with Nora West-Allen (Jessica Parker Kennedy) allowing herself to vanish from existence after a new timeline was created, Team Flash -- especially Nora's parents, Barry Allen (Grant Gustin) and Iris West-Allen (Candice Patton) -- were dealt a massive blow. The Season 6 premiere will deal with the aftermath of that ending right away, as Patton has confirmed the episode picks up approximately 10 seconds after the Season 5 finale.

"Season 6 picks up like 10 seconds after Season 5, so Barry and Iris are still dealing with the loss of Nora, it's very raw, it's very fresh," Patton told ComicBook.com. "We see them very early on, Episode 1, really grappling with how to deal with the loss of Nora so they can move forward in a healthy way and deal with the upcoming 'Crisis on Infinite Earths.'"

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Last month, current showrunner Eric Wallace stated the entirety of Season 6 would deal with the events of "Crisis," which had long been teased by the show since its first episode aired back in 2014. With those problems, plus two new main villains -- the first one being Bloodwork (Sendhil Ramamurthy) -- set to plague Team Flash in their own respective "chapters" for the season, the Fastest Man Alive and his crew may have more trouble on their hands than ever before.

Returning Tuesday, Oct. 8 at 8 p.m. on The CW, The Flash stars Grant Gustin, Candice Patton, Carlos Valdes, Danielle Panabaker, Tom Cavanagh, Jesse L. Martin, Danielle Nicolet and Hartley Sawyer.

KEEP READING: The Flash Season 6 Photo Reveals Barry's New 52-Inspired Costume