A brilliant scientist wakes up in a strange hotel room with a titanium briefcase shackled to his wrist and no idea how it got there. As he desperately tries to stay a step ahead of the international terrorists, CIA, and MI-6 agents chasing him across the globe, he realizes that he is the only person who can keep this mysterious briefcase from being delivered to Washington-and thwart what could be the deadliest terrorist attack in history.