Emmy Award-winning actor Jon Cryer has been cast as iconic DC comics villain Lex Luthor on The CW's Supergirl.

Best known for his roles in the John Hughes classic Pretty in Pink and on the long-running comedy Two and a Half Men, Cryer will debut Sunday, March 17 in an episode titled "O Brother, Where Art Thou?" and then continue in a recurring role.

The official synopsis for the episode states, "Lex Luthor reaches out from prison to enlist Lena (Katie McGrath) into one of his plans and will stop at nothing to get her on board, even if that means leveraging the life of one of her friends."

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Photo credit: Jordon Nuttall

“We are enormous fans of Jon Cryer, and he was instantly our dream actor to play the iconic role of Lex Luthor," Supergirl executive producers Robert Rovner and Jessica Queller said in a joint statement when Cryer's casting was announced. "Jon is a super-talent, and the fact that he played Lenny Luthor in Superman IV brings an added layer of legacy to his casting. We’re beyond thrilled to welcome Jon to the Supergirl family.”

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“We’re beyond excited to introduce iconic villain, Lex Luthor, to Supergirl and to weave him into our story this season," Rovner and Queller added. "We’ve talked about having Lex on the show since it’s inception and we’re excited to have him finally arrive. We can’t wait for him to shake things up in National City and watch him go toe to toe with not only Supergirl, but his sister Lena Luthor.”

Airing Sundays at 8 p.m. ET/PT on The CW, Supergirl stars Melissa Benoist as Kara Danvers, David Harewood as Martian Manhunter, Mehcad Brooks as Jimmy Olsen and Chyler Leigh as Alex Danvers.