Star Trek: The Next Generation's Data (Brent Spiner) is a classic android, complete with encyclopedic knowledge and literal thought processes. He's one of the series' Soong-type androids (crafted by Dr. Noonien Soong and featuring positronic brains) and arguably the most significant one, given his prominent position on the USS Enterprise. The expectation with androids is that they're at least somewhat detached from human emotion and the external things that can affect those, but Data proved otherwise.

In Season 1, Episode 3, "The Naked Now," the Enterprise goes investigates the SS Tsiolkovsky, a ship that went incommunicado on the way to investigate a dying star. When the Enterprise manages to contact them, Data is confused by the disorderly sounds of the crew before an explosion cuts them off; Picard (Patrick Stewart) orders some of the crew over to the Tsiolkovsky to investigate.

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They discover the ship in disarray -- with Data describing the surroundings as the aftermath of "a wild party" -- and soon realize that the crew, and many of the items on the ship, blew out into space through an open emergency hatch. Yar (Denise Crosby) finds a group of ten people on board, all of them semi or fully unclothed and frozen to death, and deduces that they also vented the ship's heat through the hatch. La Forge (LeVar Burton) comes across frozen crew members and unintentionally touches a body, accidentally contaminating himself.

It becomes clear that he's been affected by whatever they encountered on the Tsiolkovsky when he starts uncontrollably perspiring and snapping at the others when they try to help him. Dr. Crusher (Gates McFadden) quarantines him to the sickbay, but when she goes into her office, he flees and starts accidentally spreading the infection by touching other members of the crew.

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Riker (Jonathan Frakes) asks Data to look up a historical incident that bears similarities to the Enterprise's current predicament. The records reveal that carbon molecules infused water and caused alcohol-like intoxication (this references Star Trek: The Original Series Season 1, Episode 6). Dr. Crusher uses this information to create a cure, though her first attempt doesn't take.

Data is sent to take Yar -- who became hypersexual after coming into contact with the intoxicating mystery illness -- to the sickbay, in part because Picard believes that Data will be immune to the illness. Yar has changed into a provocative outfit and attempts to seduce him. She shares some of her personal history with Data, and he genuinely seems affected by her emotional confession. She touches him, and the infection actually spreads to him, which prompts Data to respond positively to her seduction before following her into her quarters.

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Later, Data reappears on the bridge and behaves "drunkenly," just like the other crew members have done. Picard is confused by his behavior, given that Data is an android. However, he is apparently not immune to the water intoxication spreading through the ship. Data is sent to help in engineering since he's the only one who can fix the ship in time to avoid imminent doom. Ultimately, he and Wesley (Wil Wheaton) manage to save the ship and Dr. Crusher vaccinates the crew against the illness.

This unusual TNG episode proved that androids, at least Soong-type androids, might be immune to alcohol and its effects, but polywater intoxication affects them the same as humans. While Data cannot get drunk in the traditional sense, this is the closest audiences get to a tipsy Data.

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