The Simpsons have caused many explosive events in their hometown of Springfield over the years -- both figuratively and literally. But in one notable instance, the town of Springfield actually proved exhausted by all this and decided to do something about it.
Let's look at when Springfield finally called out the Simpsons in Season 23's "At Long Last, Leave," and how the town actually made some good points.
"At Long Last, Leave" opens with the Simpsons watching a news broadcast announcing that Springfield will go through a disaster drill, advising the whole town to take shelter. Deciding to explore the empty town, the family is stunned to discover it was a ruse to distract the Simpsons from a secret town meeting. This is because the subject is the Simpsons themselves -- and how the town has grown exhausted of them and their antics. The family makes their presence known but the townspeople don't back down. The surprising part is that their problems with the family end up having more truth to them than the Simpsons would like to admit.
Homer and Bart are both called out for their destructive natures, with the pairs respective buffoonery and explosive pranks escalating to the point of costing the city millions in repairs. Lisa's eco-friendly campaigns have exhausted the town and drained them of even more funds while having a little genuine impact on the betterment of the city. Cookie Kwan points out that Maggie is a surprisingly terrifying infant, which elicits a non-verbal threat from the baby. Marge tries to reason with the town and argues for their place in Springfield -- something that gets Mayor Quimby to point out that Marge's ability to prey on the empathy of the town and force them to forgive her family is what makes quietly her the worst Simpson of them all.
Despite the last-minute efforts of Ned Flanders to change their mind, the Simpsons are exiled from Springfield and forced to move on to another town. While it's a cruel act from Springfield -- especially considering their own idiosyncrasies and flaws -- it does make a certain amount of sense. Homer and Bart had previously leveled entire sections of the town just on their own. The patriarch of the family even almost got all of Springfield killed in The Simpsons Movie. In that way, it makes sense for the often-cash-strapped town to see him and Bart as serious threats to their financial security.
Lisa and Marge's "crimes" are far less bombastic than the rest of the family, but they both have dictated the whims of Springfield and essentially guilted the town into forgiving them for their assorted wild actions. To an extent, it makes sense for the town to turn on the Simpsons as a whole. The Simpsons eventually end up in the "outlands," a wild and largely uncivilized stretch of land. While the family quickly adjusts and makes a real home for themselves, Marge initially misses Springfield -- until a secret date night back in the town with Homer is exposed, and the town threatens to shoot the pair on sight. Exhausted with the people she considered friends and neighbors, Marge calls out all of Springfield for not accepting who they are and comes to consider exile as the best thing to happen to her family.
Soon, members of the Springfield community make their way into the outlands -- at least until the entire town relocates there and effectively rebuilds Springfield around the Simpsons. It's good that the Simpsons were finally forced to face repercussions for the years of their adventures and exploits, but it's also fitting that so long as they remained together the family could survive and thrive. And more than that, Springfield accepting them means they can also fully accept themselves -- giving the entire town not necessarily a pass for their actions but an unspoken agreement that all of them belong.