"With great power comes great responsibility." Though a form of this quote comes goes as far back as the late 1700s, its appearance in the last panel of Amazing Fantasy #15 is how it became famous. In general, it established the mantra of one Peter Parker, known in the comic book world as the Amazing Spider-Man.

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It's something he continually strives for in his role as one of Manhattan's super-powered protectors. Yet, there have been moments when the Peter Parker principles have faltered. Sometimes he did it on purpose. In other situations, it occurred due to the Parker Luck. No matter how it occurred, they were moments where Peter forgot those immortal words.

10 Uncle Ben's Death

Peter Parker cries, realizing he's responsible for Uncle Ben's death in Marvel Comics

The reason Mr. Parker applied the quote to his life was he totally ignored it at the start of his superhero career. In an origin that has since become historic, Peter uses his newfound powers to become a famous wrestler. His goal is to make money to help Aunt May and Uncle Ben. Yet, it causes a change in him.

This nebbish young man who was the light of his aunt and uncle got selfish. So, instead of stopping a thief, he let him go while he counted his money. The result was Uncle Ben's unnecessary death. From that point on, Peter knew he needed to be responsible with his powers.

9 Spider-Man No More

Peter quitting his her role resulted in the Kingpin.

Peter resigned his web-shooters several times in his career. However, none of them were so poignant and irresponsible as the first time in The Amazing Spider-Man #50. Then again, with everything hanging above this Marvel hero's head, even Superman might have temporarily thrown in the towel.

It was an accumulation of issues that made Peter forget his principles. Problems at college, constant berating by J. Jonah Jameson, and another bout of illness for Aunt May prodded the young Parker to toss his Spider-Man costume in the trash and walk away. Unfortunately, this didn't stop crime from going up or halt the Kingpin's attempt to rule the city. It was the rescue of a night watchman that returned Peter to his senses and made him don the red-and-blue once again.

8 Gwen Stacy's Death

Amazing Spider-Man 121 header

Things got extremely real for Peter in Amazing Spider-Man 121 & 122. First, Norman Osborn, after being free of the Green Goblin persona for years, snaps and becomes the villain again. Second, he kidnaps Peter's girlfriend at the time, Gwen Stacy. Spider-Man and Goby fight on top of the George Washington Bridge and cause Gwen to fall. Though Spidey quips about how good he is at rescues, the harshness of the grab causes Gwen's neck to snap.

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This breaks Peter. He aggressively flees the authorities, doesn't stop to help his addicted friend, Harry Osborn, and tries to bring the Goblin to justice. However, the villain's own glider impales him. Hollowed out, he doesn't relish the senior Osborn's death. While Goblin was partly responsible for Stacy's death, Spider-Man is equally at fault.

7 Creating Venom

Amazing Spider-Man #300 - First Appearance Venom

When Peter appeared in his black costume on the cover of Amazing Spider-Man 252, no one knew that it was going to be a moment where his responsibility was forgotten. He thought it was a piece of technology created from another machine on the Secret Wars world. Turned out, it was part of an alien race known as the Symbiotes.

Eventually, he realized what it was and used sound waves to get rid of it. However, Peter didn't further investigate what happened to the alien. He was just glad it was gone. If he had done so, Spidey would've found it hiding in a church's bell tower. Then, it might not have found Eddie Brock and created Venom.

6 Hits Mary Jane

In the "Clone Saga," Peter accidentally strikes a pregnant MJ.

Peter has been angry at his on-again, off-again, on-again girlfriend and partner Mary Jane. However, he has never gotten to the point of being verbally or physically abusive. Except for one moment where he forgot how responsible he needed to be. Especially since MJ was pregnant at the time.

It took place during the Clone Saga. When Peter found out he wasn't really the original (he actually was, but it's a long story), he got into a battle with the man who was the first young Parker, Ben Reilly. When MJ tried to stop them, Peter slapped her so hard she collapsed several feet away. Though she forgave him, Peter didn't forgive himself. The result was a temporary disappearance of the Parker Principle.

5 Revealed His Identity

An image of Peter Parker after he publicly announced he's Spider-Man

In a pivotal moment during the first Civil War series, Peter stepped up to the podium, pulled off his mask, and revealed his identity to the world. Some would say this was a sign of responsibility when it came to hero registration. Others believed it was utterly wrong.

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This is especially true after everything that happened after the revelation. Aunt May's home was destroyed, so Peter, MJ, and the elder Parker needed to move into Avengers Tower. Then, May was shot by an assassin's bullet meant for Spider-Man. Eventually, Peter followed the trail of that weapon to the Kingpin, who he nearly killed. During this whole storyline, all that Spider-Man dealt with is great power.

4 Reset History

Peter made a deal with the "Devil" go get things back to normal.

Though it doesn't come out frequently, Peter Parker has a bit of a selfish streak. It was seen in his origins as a wrestler. Later, it came out after the events of Civil War. To put it simply, the Parker Luck was at its finest and he blew it.

So, instead of admitting he royally messed things up with MJ and Aunt May, he made a deal with Mephisto to reset history so all his screw-ups would disappear. However, in doing so, his entire life would reboot, including his marriage to MJ. It was one of the weakest moments in Peter's life and one filled with irresponsibility.

3 Wanted To Kill Scarlet Witch

Spider-Man House Of M Peter Parker Chat With Uncle Ben

House of M didn't only affect the X-Men and other mutants across the globe. It also caused problems for many Avengers, Spider-Man included. When the Scarlet Witch transformed the Earth into something different, Peter's Uncle Ben and Gwen Stacy were still alive. Furthermore, he was a father.

When Wolverine confronted him about this false reality, Peter did show his responsibilities and join the rest of the affected heroes. However, he also showed a fraying of his principles when he admitted he wanted to kill the Scarlet Witch for what she did to him.

2 Let Doctor Octopus Take Over His Body

Peter dropped the ball when he let Dr. Octopus take over his body.

Peter could have done much more to stop Otto from taking over his body and becoming the Superior Spider-Man. This is a man who battled every type of villain that crossed his path. Surely, he could've had more responsibility.

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Yet, he gave away his power and management to Otto and simply faded away. Meanwhile, the former Dr. Octopus changed everything up. It took an escalating series of situations for Peter to return and regain his power and responsibility.

1 Destroying Parker Industries

Parker Industries' Baxter Building

This action can be considered both responsible and irresponsible. It depends on who provides their opinion on the matter. During Secret EmpireOtto Octavius assumed the role of the Superior Octopus and attempted to take back Parker Industries. After all, he was the one who created it in the first place when he was in Peter's body. He destroyed several office locations before he encountered Spider-Man.

Here's where it gets hairy. On the one hand, destroying all of the company's data so it wouldn't get into evil hands was the responsible thing to do. On the other, Peter used his power irresponsibly to destroy the company's capital and cause its employees to be out of work. There should've been another way to defeat Otto while maintaining production integrity.

NEXT: Spider-Man: 10 Times Peter Parker Was His Own Worst Enemy