Warning: The following contains spoilers for Spider-Woman #5 by Karla Pacheco, Pere Perez, and Frank D'Armata, & VC's Travis Lanham, on sale now.
At the end of Spider-Woman #4, her mother, Miriam, made a shocking move: when Octavia Vermis attacked Miriam's lab on Wundagore Mountain, Miriam threw Jessica Drew into the line of fire, telling them to kill her and spare her grandchild.
Now, Jessica has learned the truth behind everything and while Miriam claimed to have survived the assassination attempt on her life by Hydra years before, this Miriam Drew is a clone, and her memories include an intense hatred of Spider-Woman. Miriam even tells her son Michael to get Rebecca to safety so that she can deal with both the monsters, referring to Octavia Vermis and Jessica Drew. As Spider-Woman says later in the issue, Miriam is a "freakin' murder clone."
Luckily for Jessica, Michael refuses to listen and saves his sister, who his mother then claims is an "abomination." This is when Miriam explains why she hates her daughter so much, saying that Jessica betrayed her own family. This goes back to the origin of Spider-Woman and the reveal of how she gained her powers and how she became the superhero that she became. Sadly, for her mother, she only saw the evil that was accomplished surrounding her daughter's birth. This was told in Spider-Woman: Origin in 2005 by Brian Michael Bendis, Brian Reed, Jonathan Luna, Joshua Luna, and VC's Cory Petit. This was the series that showed Jessica's parents, Jonathan and Miriam, were working on cutting-edge experiments. However, when a radiation blast hit a pregnant Miriam in the stomach, Jessica was born with superhuman powers. In Jessica's earliest memories, her dad told her Miriam died in labor. However, that was a lie, as this series showed she lived and watched Jessica live in a coma for years.
Jessica woke up, and Hydra had Mentallo brainwash her, giving her fake memories, making her believe they were good guys fighting the good fight, and sent her to kill Nick Fury. Luckily for Jessica, she learned the truth from Fury and ended up battling Hydra. She learned her mother was still alive and went to save her, only for Hydra to beat her there and assassinate her mom in a motel room. From that point on, Spider-Woman believed her mother was dead. Jessica has now found her mother apparently still alive, but also found a mother who blamed her for everything. Miriam had no idea that Metallo brainwashed Jessica, nor did she likely care. She only knows that Jonathan turned Jessica into a monster for "them," referring to Hydra. Miriam said she waited for Jessica to come out of her coma, and when she did, she joined Hydra, proving to her that Spider-Woman was a monster just like her father. Miriam said that Jessica broke her heart. She said she died for her, and Spider-Woman ran around the world using powers Hydra gave her while Jessica's own niece Rebecca was dying just for being like her.
It sent this clone of Miriam to the brink of insanity. Even when Octavia Vermis was trying to kill them both, Miriam couldn't stop trying to kill Spider-Woman. Even when Rebecca begged her grandmother to stop because they needed Jessica to save her, Miriam was so far gone that she wanted Jessica dead more than she was willing to see the harm it would cause. Miriam kept taking more and more of the serum, making her stronger and driving her insane.
Finally, it took Octavia Vermis attempting to take Rebecca before Miriam stopped fighting Spider-Woman and sacrificed herself. But, even in the end, she wouldn't forgive Jessica and said she was only doing it to save Rebecca. With that, Spider-Woman learned there were more out there like Miriam, and her fight was only just beginning.