The new PlayStation game Spider-Man: Miles Morales pits Miles against one of Marvel's greatest villains in the Roxxon Corporation. Led by CEO Simon Krieger, Roxxon is a classic example of an evil corporation, utilizing a new dangerous type of energy called Nuform. Unconcerned about the consequences, they have set up a new headquarters in Harlem, Roxxon Plaza. Meanwhile, Miles's mother is running for a position in city government on a platform of opposition to Roxxon.
A new gang known as the Underground has also emerged, committed to opposing Roxxon by using the experimental Nuform energy to build high-tech weapons. But Roxxon has its own private army of trigger-happy armor-clad enforcers, revealing the company is every bit as committed to evil as their comic counterpart.
Roxxon was introduced in 1974's Captain America #180 by Steve Engelhart and Sal Buscema, when its president is kidnapped by the villainous Serpent Society. Simon Krieger had yet to appear, and the company's President was Hugh Jones. The Serpent Society used the magical Serpent Crown to influence Jones, having his company use their oil-drilling equipment to try to raise the sunken continent of Lemuria. The plot is stopped, but much later, Hughes (still under the Serpent Crown's influence) actually tries to overthrow the U.S. government.
Roxxon also makes numerous appearances in Iron Man comics, including in the infamous "Demon in a Bottle" story where Tony Stark teamed up with Prince Namor to stop Roxxon illegally dumping waste on an island in the Pacific. In Iron Man #142 by David Michelinie, John Romita Jr., and Bob Layton, a Roxxon satellite called Star Well I is used to harvest solar power and beam it back to Earth, but ends up killing hundreds and wiping out a small town. When Tony Stark flies up to Star Well I, Roxxon tries to kill him. Simon Krieger makes his debut in Iron Man: The Iron Age by Kurt Busiek and Patrick Zircher, where he and other Roxxon board members try to have Tony Stark's parents killed as part of a hostile takeover of Stark Industries.
More recently, Thor: God of Thunder #19 by Jason Aaron and Esad Ribic, introduced a new Roxxon CEO, a Machiavellian minotaur named Dario Agger. Throughout Thor, Roxxon unleashes devastating amounts of pollution, slaps Thor with a lawsuit for intervening, and partners with various villains as part of shady banking and war profiteering ventures. Agger also leads his company in joining Malekith the Accursed's invasion of the Ten Realms, committing war crimes in Alfheim and other worlds and then reaping profits through slavery and resource exploitation. He even joins Malekith's armies in their invasion of Earth during "War of the Realms."
After the company got off with betraying the human race, the Hulk targeted Roxxon for exemplifying everything wrong with the world. In Al Ewing and Bennett's The Immortal Hulk series, Banner destroys the server farms that the company used to influence social media and generate online propaganda. In response, Agger partners with a memory-warping alien named Xenmu to make the public despise the Hulk while having positive feelings toward Roxxon and Xenmu, not caring that the alien keeps eating his employees.
This willingness to hurt anyone for the sake of profits is a key part of Roxxon's identity in Spider-Man: Miles Morales. Their irresponsible use of Nuform results in a truck full of Nuform blowing up a bridge. They blame the explosion on Spider-Man and order their paramilitary troops to murder him, echoing real-world police killings of young Black men. Like so many Roxxon CEOs in the comics, Simon Krieger uses propaganda to spin the story, notably doing interviews on J. Jonah Jameson's podcast.
The company has also appeared in the MCU. They feature briefly in Iron Man 2 and are responsible for an oil spill in Iron Man 3. They also appear in the MCU Netflix series, Daredevil, where they sue a man who got cancer working for them. In Season 2, Elektra learns they are working with the assassins of Hand (an arrangement also seen in Iron Fist as they help facilitate the Hand's drug trade). In fact, their misdeeds in the MCU stretch back to the '40s, something addressed in the Agent Carter series.
Roxxon is a company driven purely by the desire for profits. However, unlike other villains, they cannot be defeated. If a CEO is taken out by one of Marvel's heroes, then he will just be replaced by another. In fact, in the distant future of the Spider-Man 2099 comics, Roxxon continues to exist as a monolithic evil corporation, proving just how unstoppable resilient they really are.