WARNING: The following contains spoilers for Amazing Spider-Man #57 by Nick Spencer, Mark Bagley, John Dell, Andrew Hennesy, Andy Owens, Rachelle Rosenberg, Edgar Delgado & VC's Joe Caramagna, on sale now.
Spider-Man has battled Norman Osborn for decades. His first fight with the Green Goblin came in Amazing Spider-Man #14 in 1964 by Stan Lee, Steve Ditko & Art Simek. He met Harry Osborn the next year, and the two became best friends until after Norman's death when Harry lost his mind and became the Green Goblin.
Through all that time, Norman had tormented Spider-Man, killing Gwen Stacy and eventually started his planning for the Clone Saga. Harry blamed Peter Parker for both his father's death and that of Gwen Stacy and ended up dying trying to bring down Spider-Man. Following his battle with Kindred, Spider-Man has had enough and told Norman Osborn he is finished with the Osborn family once and for all in Amazing Spider-Man #57.
After Spider-Man showed up and threatened Norman Osborn, it was revealed that Norman had faked returning to evil to get his son to safety and stop his reign of terror. However, Spider-Man didn't buy it for a second and became overly aggressive with Norman. It made sense on multiple levels. For one thing, Kindred had killed and resurrected Spider-Man over and over in the cemetery and forced Peter to face up to his failures throughout the years. Being Spider-Man, he wouldn't accept any responsibility for anything that happened in the past, at least not outwardly to Harry Osborn. Now that Harry was captured, Spider-Man doesn't even want to consider it anymore.
Norman explained to Peter that he was cured, and the sins that Sin-Eater took from him silenced the voices in his head, the mental illness that caused him to lose control as the Green Goblin for all those years. He begged Spider-Man to help him save Harry, but Peter is finished with this and has no desire to help anyone in the Osborn family again. Spider-Man pointed out that Norman had amnesia and was cured in the past before returning to villainy. Now, he has been cured by the Sin-Eater, and it is the same story over and over again.
For Harry Osborn, it is worse. Kindred just put Spider-Man through the worst moments of his life. He tortured him and killed him in a seemingly endless cycle. He kept demanding that Spider-Man admit to something. It is still unclear if Kindred just wanted Peter to admit that he was as much to blame for what has gone wrong in his life or if there was something deeper, perhaps something that might have to do with his deal with Mephisto. Spider-Man told Norman straight up that nothing binds them together. Norman is not a "father figure," and Harry was really not much of a friend. He told Norman to let him rot and never to free him again.
Spider-Man still refused to take responsibility for anything. He said that Norman, and vicariously Harry, blamed him for everything, but it was time that they took responsibility for themselves. Norman begged Spider-Man to help him save his son, and Peter refused, saying that if he ever hears that Harry was freed again, he will bring the place down around Norman and bury him with it. When Norman reached out and again asked Spider-Man to help him, the web-slinger started to beat Norman mercilessly until he realized he had lost control. Spider-Man left, leaving Norman Osborn alone to find a way to save Harry Osborn.