"I can't really, I have my own show so I will not be a regular on the Marvel S.H.I.E.L.D. show. But I am glad people are so excited about that. I think it's a good idea," Caplan said, adding, "Maybe I could do some little thing."
The show Caplan is talking about is the new Showtime series called Masters of Sex. It stars Caplan as Virginia Johnson and Michael Sheen as William Masters, two real-life people who were involved in researching human sexuality back in the '50s. It will take up much of the time that she could have otherwise devoted to S.H.I.E.L.D. but, as she says, there's no reason to rule out a cameo here or there.
Though using Item 47 as a bridge between The Avengers and S.H.I.E.L.D. would have been a good idea, Joss Whedon has made it no secret that the two properties are going to be separate entities. He has said S.H.I.E.L.D. will be "autonomous" from The Avengers and will feature "new characters." We aren't counting Maximiliano Hernández and Titus Welliver out just yet, though. With Clark Gregg's Agent Phil Coulson gone, there should be some connecting thread that ties S.H.I.E.L.D. back to the Marvel Cinematic Universe.
Whedon will co-write S.H.I.E.L.D. with his brother Jed Whedon (Spartacus: Vengeance), and Maurissa Tancharoen (Spartacus: Gods of the Arena), both of whom also worked on Whedon’s Dollhouse series at Fox. S.H.I.E.L.D. marks Joss Whedon’s return to television, where he created the critically acclaimed Buffy the Vampire Slayer, Angel, Firefly and Dollhouse.
Production on S.H.I.E.L.D. will begin immediately, but there are no further details regarding casting for Marvel TV’s first live-action project. The show is slated to join ABC's fall 2013 lineup.