Twentieth Century Fox has offered Deadpool to Sin City director Robert Rodriguez, Production Weekly and The Playlist report. Not that offering Rodriguez necessarily means anything; after all, Fox offered him the Planet of the Apes prequel, too.
However, for what it's worth, The Playlist says the director is considering the film, which is being penned by Zombieland screenwriters Rhett Reese and Paul Wernick. Last we heard, Green Lantern star Ryan Reynolds was on track to reprise his role from X-Men Origins: Wolverine. The actor told MTV as recently as January that he was talking to Reese and Wernick "every single day."