Despite all the problems with its fandom, Rick and Morty remains one of the most unique animated series to come out in the last decade. Most of the credit for its popularity goes to the often-morbid humor smoothly embedded into the adventures of a maniacal grandfather and his skittish grandson.
Rick and Morty never pushes its brand of comedy at viewers, but rather expresses it in a nonchalant manner. It feels like the story and its characters don't really care about how the audience is going to react: a central element of the show's charm. In Morty's immortal words, "Nobody exists on purpose, nobody belongs anywhere, everybody's gonna die. Come watch TV."
10 Beth — "I Squanch My Family.”
The family are invited to Birdperson's wedding with Tammy, which includes a number of Rick's friends and allies. Among them is Squanchy, an eccentric cat-creature with a penchant for replacing nouns, verbs, and other parts of speech with his name.
Beth wonders if repeating a single word in different scenarios might "become tedious and worn out," to which Rick responds that "it is more contextual than literal." However, when Beth tries to express her affection for her family, both Squanchy and Rick are stunned by her use of "squanch," implying that there is a third factor involved: tone. It's funny because nobody explains to her why it's "gross."
9 Summer — “If I Die, Don't Eat My A**; That'd Be Weird.”
Trapped on a living planet, Summer and Morty find a crashed spaceship, where they start getting high on alien brake fluid and end up killing an actual thunder god.
Prior to their accidental success, however, Summer laments that they have "no life skills" whatsoever, and tells Morty that it would "be weird" if he ate the buttocks off her corpse. This line is extra hilarious because of the bizarre visual it generates in the audience's minds.
8 Rick — "You Just Looked Right Into The Bleeding Jaws Of Capitalism & Said 'Yes Daddy, Please.'"
After the conclusion of the narrative hyperloop that is Story Train, the real(?) Rick goes on a rant, claiming that Morty's "only purpose in life is to buy and consume merchandise," before lapsing into an uncomfortable display of affection for his grandson.
This quote's humor is powerful because it caricatures consumerism by exaggerating its merits beyond the suspension of disbelief, not to mention referring to capitalism as "daddy." The latter is a whole can of worms by itself.
7 Jerry — "The Milk People Don't Have A Patent On Simple Rhetorical Questions!"
Like always, Jerry is blissfully unaware of the simulation he is accidentally transported into, and acts out his daily ritual as if everything is normal. For some reason, he plagiarizes the "Got Milk?" catchphrase for use on apples, which his imaginary bosses commend him for.
In an uncharacteristic turn of events, Jerry acknowledges that his "'Hungry for Apples' is just a rip-off," but then bursts into a tirade about "patent[s] on simple rhetorical questions." Peak Jerry-based humor has little logic behind it, but that's exactly the point.
6 Morty — "You Know, You're Really Playing With Fire When You Burst In Here Like That, Man."
Jerry enters Morty's room without knocking and finds him m*********, although the realization doesn't sink in until his son says, "I mean, I’m sitting in here, I’m 14! I got a computer in here, you know!"
Jerry grasps the situation quickly enough, but Morty stretches the awkwardness further, forcing his father to repeatedly explain that he gets it. Rick and Morty is known for extracting comedy from embarrassing circumstances, and this set of lines is a prime example.
5 Summer — "At Least The Devil Has A Job. At Least He’s Active In The Community."
Rick is infuriated when he discovers that Summer's employer is actually Lucifer in human disguise. He gets into a fight with Mr. Needful, but his granddaughter points out that she "like[s] working here."
Summer asserts that her boss' real nature is irrelevant because he "has a job... he's active in the community," adding that her grandfather does nothing more than "eat our food and make gadgets." Although Rick is technically right, Summer's snarky burn is amusingly accurate.
4 Mr. Meeseeks — "We Will Get All Strokes Off His Game... When We Kill Him!"
Jerry's request—getting two strokes off his golf game—prompts his Mr. Meeseeks to spawn several more of itself to assist in the seemingly impossible task. It gets more and more stressful when Jerry makes no progress, which inadvertently tortures the Meeseekses by forcing them to stay corporeal beyond their limits.
To resolve the problem, one of them suggests that killing Jerry would be an acceptable solution. The declaration goes against everything the Meeseeks "species" stands for, which is why it sounds so hilarious.
3 Jerry — "We Understand Genocide! We Do It Sometimes!"
Doctors at an alien hospital ask Jerry's permission to reconfigure his genitals into Shrimply Pibbles' heart, since "the configuration of veins, the ratio of thickness to elasticity" are perfect for the transplant.
Jerry is naturally averse to the idea when the alien doctors begin talking about genocides on other planets. Not to be outdone, Jerry angrily informs them his species "understand genocide," because they "do it sometimes!" That's his takeaway from the whole argument.
2 Many Characters — "You Son Of A B***h: I'm In!"
"One Flew over the Crewcoo's Morty" contains the most meme-worthy moments in all five seasons of Rick and Morty. It starts with an assortment of heist-related characters saying this line when Rick hires them for a job.
However, it gets a lot more confusing when Heistotron manipulates random strangers into partaking in its heists, all of who also repeat the same exclamation of agreement—a quote that throws some pretty heavy shade over the heist film genre.
1 Rick — "First Off, I Always Slay It, Queen."
Morty goes on adventures with his new dragon pal, Balthromaw, who makes a cavernous burrow for himself below the Smith residence. However, a blast of fire erupts from the living room floor, scaring Rick and Summer who are watching Interdimensional Cable at the time.
Rick prepares to end Balthromaw's life when Summer asks him if he's "gonna slay it." His retort—"first off, I always slay it, queen"—will go down as one of the sassiest lines in the show's history.