While most pilot-casting announcements are full of good news for both the actor hired and the new project, this first one from TVLine signals bad things for an existing show.

The site reports Will Arnett has signed on to star in Greg Garcia's still-untitled CBS sitcom. Why's this bad news? Well, Arnett's NBC series Up All Night hasn't officially been canceled, but this move might be what finally yanks the faltering sitcom off of life support. Anyway, this new project by the creator of Raising Hope and My Name is Earl features Arnett as a divorcee whose parents are going through their own marital troubles. Garcia has another pilot in the works at CBS called Super Clyde, starring Harry Potter's Rupert Grint.

Meanwhile, ABC's Killer Women has found its leading man in Marc Blucas (Buffy, Necessary Roughness). The Hollywood Reporter got the scoop not long after Battlestar Galactica alum Tricia Helfer's starring role in the series was announced. Blucas is set to play DEA agent Dan who has a sexual, though strictly physical, relationship with Helfer's Molly Parker.

From action to comedy, TVLine reports that Tim Meadows has joined the Fox sitcom The Gabriels. Created by Justin Hurwitz (The League) and Andre Gurland the series focuses on the buttoned-up title family of a Wisconsin town filled with busy bodies. Meadows will play "straight-laced" Principal Tom.

According to THR the network sussed out the female lead for ABC's Spy, a remake of Simeon Goulden's British series. Goulden has written the US pilot version which will now star Paget Brewster (Criminal Minds) as Rob Corddry's ex-wife and Mason Cook's mother. Brewster's Erica Elliot is a cold neurotic, basically the polar opposite of Corddry's warm and loving father.

ABC also nailed down Steve Zahn (That Thing You Do, Treme) for Awake creator Kyle Killen's next pilot Influence, according to TVLine. Zahn plays bi-polar Clark, one of two brothers "who head a unique agency designed to attack their clients’ problems using the real science of human motivation and manipulation."