In One Piece, Kaido is known as the world's strongest creature. He is also the Governor-General of the Beasts Pirates and one of the Four Emperors ruling over the New World. He's incredibly physically strong and is very durable, making him extremely difficult to kill. The Devil Fruit he consumed was the Uo Uo no Mi, Model: Seiryu, which lets him turn into a full serpentine Azure Dragon and a human-dragon hybrid.

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However, there are many anime characters who could give Kaido a run for his money and even defeat him. From Kirito's swordplay to Sailor Moon's expansive set of abilities, all of these anime fighters could defeat him with their intelligence mixed with their varied powerful skills.

10  Kirito Is An Incredibly Powerful Fighter (Sword Art Online)

Kirito Sword Art Online Enters The Scene

To Kirito from Sword Art Online, Kaido might as well be just another beast or floor boss he has to defeat. Kirito has been through many tough fights in his series and come out victorious. Considering his string of victories, it's highly likely that he would be able to beat Kaido. The battle would be long and drawn out between them, but Kirito would ultimately win due to his ability to strategize against his opponent.

9 Akira Shiroyanagi Could Trick Kaido Into Thinking He Has Powerful Abilities (Battle Game In 5 Seconds)

Battle Game In 5 Seconds

Akira Shiroyanagi in the new anime Battle Game In 5 Seconds has the uncanny ability to do whatever he wants, as long as he makes his opponent believe that he has that ability. Given how manipulative and clever Akira already is, he could easily manipulate Kaido into thinking that he has extremely powerful abilities and use that to his advantage to defeat him. He also is smart enough to analyze Kaido's abilities and use his gaming knowledge and experience to see just what he's dealing with.

8 Aiz Wallenstein Is An Extremely Tough Warrior (Is It Wrong To Try To Pick Up Girls In A Dungeon!?)

Aiz Wallenstein clashing swords with Bell Cranel

Aiz Wallenstein has presented in the anime Is It Wrong To Try To Pick Up Girls In A Dungeon!? as a powerful swordsperson. She has the skills to back up the claims about her, and she even trains Bell briefly early in the anime.

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Aiz's expert swordsmanship and agility would easily help her out against Kaido, and she could defeat him with her strong set of skills in hand. It would be a close fight, considering how tough Kaido is, but Aiz would win against him in the end.

7 Azusa Could Wipe Him Out With Her Arsenal Of Magic (I've Been Killing Slimes For 300 Years And Maxed Out My Level)

azusa slimes happy

Azusa from I've Been Killing Slimes is an extremely powerful isekai protagonist who reincarnated as a witch and has lived for three hundred years as one so far. During that time, even though she mainly defeated slimes for the sake of XP and money, she also acquired many magical abilities. She can even create her own spells to help out her allies with specific needs, and he proved repeatedly that she's the strongest person in the entire series. Azusa's range of victories, from beating Beelzebub to defeating Pecora, show that she has what it takes to take out someone as tough as Kaido.

6 Sailor Moon's Skillset Is Too Expansive For Kaido To Handle (Sailor Moon)

Sailor Moon Usagi

Sailor Moon has a range of transformations she could use to defeat Kaido. She could use the vast range of her powers to easily take out Kaido in one fell swoop, and she could even use her less-known and less-used abilities, such as her Ultrasonic Waves and Sailor Moon Kick, to incapacitate Kaido before giving him the final blow. Sailor Moon is just way too powerful for Kaido to beat given her expansive skillset.

5 Chairman Isaac Netero Could Break Through Kaido's Durability (Hunter X Hunter)

Issac Netero From Hunter X Hunter Praying In Battle

Hunter Association Chairman Isaac Netero from Hunter x Hunter might be old, but he's incredibly durable himself. He was able to sustain hard attacks from Killua and Gon when they tried taking a ball away from him during the Hunter Exam arc, and he was also one of the few fighters that could fight Meruem head-to-head in the Chimera Ant Arc.

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Considering that he was one of the most powerful Hunters in the series prior to his demise, he would win if he went up against Kaido in battle.

4 Shin Could Use His Magical Prowess To Take Him Down (Kenja No Mago)

Shin Kenja no Mago Cropped

Shin from Kenja No Mago, also known as Wise Man's Grandchild, is an overpowered isekai protagonist who could use his magical powers to literally blow Kaido away. He already proved in the anime's opening episodes that he could probably take out any of his fellow magical students if he wanted to, thanks to training under his magical grandparents for so long. Shin is also extremely smart, and he could use his intelligence to outsmart Kaido. His overpowering magic, along with his intelligence, would give Shin the win against Kaido.

3 Lunatic Could Burn Kaido With The Flames Of Thanatos (Tiger & Bunny)

Lunatic from Tiger & Bunny

Lunatic from Tiger & Bunny could use his fiery flames to take down Kaido. Kaido can only be so durable before Lunatic uses his fire to burn him away. It makes no difference how originally powerful or influential Lunatic's opponents are - he won't stop trying to kill them until he succeeds.

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No matter what Kaido might try to do to win against Lunatic, Lunatic simply won't give up until his opponent burned to death. That sheer determination, coupled with his abilities, made him one of the most terrifying opponents for anyone in Tiger & Bunny to face.

2 Merlin Could Use Her Magic And Intelligence To Take Kaido Down (The Seven Deadly Sins)

Merlin from seven deadly sins

Merlin is extremely powerful in The Seven Deadly Sins with her magical abilities and intelligence. She outwitted literal Goddesses and Demons since she beat leaders of both races in the series. Considering that victorious track record as well as keeping her abilities in mind, she can definitely outwit and beat Kaido in battle if they ever went up against each other.

1 Kaguya Has Literally No Weaknesses Going In Against Kaido (Naruto)

Kaguya Sparkling Shocked Naruto

Kaguya is literally a celestial being after eating fruit from the God Tree in Naruto. This gave her the ability to merge with nature and fully control it, fly, and read people's thoughts. These powers made her perfect as the final antagonist in her series. She could use these abilities to blend in with the nature around her and send Kaido on a wild search for her, read his thoughts to get an idea of what he plans to do when attacking her, and then use her powers to counter and beat him. If Kaido ever tried challenging her to a battle, he should expect to lose.

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