WARNING: The following contains major spoilers for Spider-Man: No Way Home, now playing in theaters.

Spider-Man: No Way Home promised a game-changing ending, and it certainly delivered as it tore Peter Parker's (Tom Holland) world apart. Peter got Doctor Strange (Benedict Cumberbatch) to mind-wipe all realities, thus ensuring no one knew his version of Peter Parker. However, in the wake of what the wall-crawler endured, it's clear the Marvel Cinematic Universe has painted him into a corner in terms of the more popular villains in future narratives.

In No Way Home, several iconic Spider-Man villains returned from Sony's Spider-Verse, which the movie used to great effect. Green Goblin, Sandman and Doc Ock arrived from Sam Raimi's movies, while Electro and the Lizard came over from the world Marc Webb built out.

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Jamie Foxx's Electro in Spider-Man: No Way Home

The problem, though, is as they kept flipping sides, working with Peter to be cured, then turning on him to stay in the MCU and attain power, he was privy to their identities too. More so, he learned that versions of them, as well as himself, existed in all universes. Thus, after they went back to their worlds, it stands to reason that Peter won't trust their namesakes in the MCU.

He saw how Norman oscillated between the Osborn persona and Goblin, and it will surely make him distrustful. While most audiences likely think Peter would want to believe in people's best selves, especially as Aunt May urged him to, without her around, he can't be blamed for being skeptical as the world's safety would depend on it. After all, there's always the chance the MCU's Norman is naturally like this and doesn't necessarily need a serum to be the Goblin.

As for Otto Octavius, Peter learned he created a machine with the power of the sun and then had the tentacles he made take control of him. While Otto was the first villain Peter properly cured, he's still someone who flipped when his wife died, and he is a great example of a sympathetic villain who started off with the best of intentions. In other words, Peter will have to gauge potential risks more so now than ever before.

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Tom Holland as Peter Parker in Spider-Man No Way Home

This may end up taking these signature folks off the table because it'd be repetitive to use them as villains, that is, unless the MCU makes a drastic change and shapes them as allies. However, that's part of their mystique, and stripping them of their evil genius personas doesn't allow them to blossom as much as they could because Spidey may be keeping a watchful eye and seeking these figures out. The same goes for Curt Connors, Flint Marko and Max Dillon, as Spidey does his best to ensure they don't become the Lizard, Sandman and Electro -- if the MCU even considers them.

That said, if their stories are done, it could open the door for a fresh face, such as Kraven the Hunter, plus seeds have been sown for Venom or maybe even Morbius the Living Vampire to become enemies down the line. Still, it seems there'll be a lack of the classic enemies because of those who spilled over from the Multiverse already, leaving fans wondering who really can live up to their evil billing as substitutes in future Spider-flicks.

Directed by Jon Watts, Spider-Man: No Way Home is now playing in theaters.

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