One of the strongest clans in the entire Naruto series, the Uchiha clan is blessed with the Kekkei Genkai of the Sharingan. It is considered to be one of the three most powerful visual jutsus, the other two being the Byakugan and the Rinnegan. The Sharingan further evolves into the Mangekyo Sharingan once the user witnesses the loss of someone very close to them and experience emotional trauma. According to Tobirama, the source of the Uchiha's power is grief born from love. Being an evolution of the Sharingan, the Mangekyo Sharingan possesses incredible power that only a few can match. Here are the 10 strongest Mangekyo Sharingan users in Naruto.
10 Izuna Uchiha
Izuna Uchiha was one of Madara's four brothers, and a valiant shinobi. Along with his elder brother, he was the first person to awaken the Mangekyo Sharingan in the Uchiha clan. The exact abilities of his Mangekyo Sharingan aren't known, but they made him strong enough to lead the clan along with Madara. At a very young age, he beat countless Senju shinobi, but he met his end after receiving a fatal wound from Tobirama's sword. Izuna's Mangekyo abilities were never revealed, but they were likely just as impressive as he was.
9 Danzo Shimura
Danzo was one of Konoha's strongest ninjas, and was tasked with handling the village's dirty business from behind the scenes. In an attempt to gain power to ensure the safety of the village, Danzo stole countless Sharingan, including Shisui's Mangekyo Sharingan. Using this eye, he could cast the all-powerful genjutsu called Kotoamtsukami which allowed him to manipulate anyone without them even realizing what was going down. Coupled with multiple other Sharingan which gave him the ability to spam Izanagi, and Hashirama's cells, Danzo was truly a menace.
8 Shin Uchiha
Shin Uchiha was a synthetic human created by Orochimaru. After gaining information on the Uchiha clan, specifically Itachi, he set out to kill Sasuke Uchiha and restore the clan. Shin had awakened the Mangekyo Sharingan through some unknown means, but the fact that he had it means he experienced emotional trauma. His Mangekyo Sharingan allowed him to mark weapons and manipulate them through telekinesis. Thanks to a body made of Hashirama's cells, he avoided the side-effects of the Mangekyo Sharingan. He was able to fight against Sasuke Uchiha and Naruto Uzumaki to some extent, which shows how strong he truly was.
7 Shisui Uchiha
Shisui, better known as Shisui the teleporter, was famed for his excellent skills as a Konoha jonin. He awakened his Mangekyo Sharingan at some point during the third great ninja war, and through it, he gained the ability to cast a powerful genjutsu known as the Kotoamtsukami. Shisui's visual prowess allowed him to cast a genjutsu so strong that he could manipulate people without them realizing what had happened. He could also manifest the Susano'o, although to what extent he could take its powers is unknown. Either way, he was a shinobi only few could defeat in the entire Naruto world.
6 Itachi Uchiha
Itachi was the son of Fugaku Uchiha, and the elder brother of Sasuke. A pacifist since childhood, Itachi never wanted bloodshed and sought power to become the Hokage and create peace. Unfortunately, he didn't get to accomplish any of that. After witnessing Shisui commit suicide, Itachi's Sharingan evolved into a Mangekyo Sharingan. His abilities were incredibly diverse. In his left eye, Itachi had the Amaterasu which gave him the ability to incinerate everything. Meanwhile, his right eye possessed the Tsukuyomi, which was a powerful genjutsu that could manipulate space and time. Thanks to his Mangekyo Sharingan, Itachi was nearly invincible.
5 Indra Otsutsuki
The first son of Hagoromo, Indra Otsutsuki, was a prodigy who excelled at everything. He inherited his father's strong chakra, and thus, the Sharingan. At some point, Indra also awakened the Mangekyo Sharingan, although just like Madara's eye, its abilities are unknown. In the anime, it's shown that Indra was capable of using the Amaterasu, but the manga doesn't back this. Indra did, however, possess the ability to use the full-body Susano'o without even unlocking the Eternal Mangekyo Sharingan, which is a huge feat in itself. He was strong enough to match Ashura in battle, which makes him one of the strongest Mangekyo Sharingan users in the entire series.
4 Obito Uchiha
Obito was a late-bloomer as his Sharingan manifested very late in the story. After witnessing Kakashi kill Rin, he awakened the Mangekyo Sharingan in his left eye. Obito's Mangekyo ability, known as Kamui, allowed him to transport parts of his body to a different dimension, making it look as if he were intangible. He could also transport those who he touched with him, and over the years, he had practiced this art to perfection. As the Jinchūriki of the ten-tails, Obito lost the ability to use the Mangekyo Sharingan, or else he would've been invincible.
3 Madara Uchiha
Madara was the first Uchiha, along with Izuna, to obtain the Mangekyo Sharingan. After years of training, he gained enormous power which he put to use against Hashirama Senju. Due to Hashirama's astronomical strength, Madara sought more power, and after his brother's death, he took his eyes to gain the Eternal Mangekyo Sharingan. Using its abilities, Madara gained the ability to use the full-body Susano'o, a casual slash from which was enough to split mountain ranges apart. Interestingly, Madara's Mangekyo Sharingan abilities were never revealed to us, despite him being the first one to awaken it.
2 Kakashi Hatake
Also known as the Copy Ninja, Kakashi Hatake was one of the most renowned shinobi in the Naruto series. Despite not being an Uchiha, his usage of Mangekyo Sharingan was admirable and even derived praise from Itachi. Kakashi was gifted the Sharingan from Obito Uchiha. After Rin's death, his eye evolved into a Mangekyo Sharingan. Just like Obito, he possessed the power to use Kamui, but his variant allowed him to warp things away at a distance. When granted access to Obito's other eye as well, Kakashi became strong enough to fight Kaguya Otsutsuki and even blitzing her, making him one of the strongest characters in the entire series.
1 Sasuke Uchiha
Topping the list is none other than the strongest Uchiha of all time, Sasuke. He awakened the Sharingan during his first mission at Tenchi Bridge. After finding out about Itachi's death, Sasuke unlocked the Mangekyo Sharingan, and it possessed some frightening abilities. Using his left eye, Sasuke could use the Amaterasu, while his right eye could manipulate the shape of the said jutsu. He also awakened the Eternal Mangekyo Sharingan after transplanting Itachi's eyes and could manifest the complete Susano'o as a result. Eventually, Sasuke's left eye would go on to become a Rinnegan with six tomoe.