Hashirama is one of the most powerful characters in the entire Naruto-verse. Many people might not believe it, but Hashirama was born a genius fighter. He was capable of using all five nature releases and was blessed with the wood release. With the wood release, Hashirama was able to tame the tailed beasts without any problems. Adding to this, Hashirama has the sage mode that further increases his power and chakra levels.
Hashirama was dubbed as the "God of Shinobi," due to his tremendous power. It's crazy to think that someone like Madara was never able to beat him. When you think about the power that Hashirama had it just makes you wonder if there is really a character who is capable of beating him. However, there are actually many characters who can take on Hashirama Senju and beat him in a fight.
10 Nagato Uzumaki
First up on the list is a member of one of the most powerful clans in the history of Naruto. Nagato Uzumaki had the Rinnegan implanted into him by Madara Uchiha. It is pretty clear that a Rinnegan will give access to all five natures as well as to the six paths technique. Nagato was never at full health while he was alive, but all of that changed when he was reanimated. Nagato showed his true skill when he fought against Killer B and Naruto Uzumaki. Both of them were perfect jinchuriki and Nagato was overwhelming them on his own. They were only saved by Itachi's intervention. If Nagato were to fight Hashirama at full then he would definitely win.
9 Sasuke Uchiha
Sasuke Uchiha is also known as the "Other Hokage of the Hidden Leaf." Towards the end of the Naruto Shippuden, Sasuke was the only person who was capable of going toe-to-toe with Naruto Uzumaki. Sasuke received a major power-up during the Fourth Great Ninja War. Hagoromo gave him half of his power that allowed Sasuke to awaken a special Rinnegan in his left eye. With the Rinnegan at his disposal, Sasuke is also able to absorb chakra and travel through dimensions in addition to the regular powers of the Rinnegan.
8 Naruto Uzumaki
Naruto Uzumaki hardly needs any introduction. He is the protagonist of Naruto. Currently, Naruto is the Seventh Hokage of the Hidden Leaf Village. Naruto has fought with the strongest characters throughout the series and throughout these fights, Naruto continued to grow. By the end of the series, Naruto is the strongest ninja in history. He has the six paths sage mode and he possesses an enormous amount of chakra. Hashirama doesn't really have a chance against Naruto. Naruto's power is far beyond the reach of a shinobi. So, this fight would be easy for Naruto.
7 Kaguya Otsutsuki
Kaguya Otsutsuki is the progenitor of chakra. She was the jinchuriki of the Ten-Tails. Kaguya is not just one of the strongest characters in the Naruto-verse, but also in the entire anime-verse. She can move through dimensions and she is the only person who can create a truth-seeking ball. Kaguya created a huge truth-seeking ball with which she was going to destroy an entire dimension. In order to beat Kaguya, it took the combined efforts of the entire Team 7 and Obito Uchiha. Hashirama has no chance of even touching Kaguya Otsutsuki.
6 Madara Uchiha
Madara Uchiha was the lifelong rival of Hashirama. Madara was the first Uchiha to awaken the Eternal Mangekyou Sharingan. He was able to tame the Nine-Tails with his powerful Sharingan. Despite all his abilities, Madara always fell short when he went up against Hashirama, however, when Madara was reanimated things changed. Madara had the Rinnegan, the wood release, and unlimited chakra. He got even stronger after he became the ten tails jinchuriki. He gained the ability of limbo and he could bring several meteors down on to the battlefield. In that form, Madara could wipe the floor with Hashirama.
5 Might Guy
He is also known as "Konoha's Sublime Green Beast of Prey." Most of the people ignored Guy's power until the Fourth Great Ninja War began. Guy demonstrated his power when he faced Kisame and he didn't give him an inch. Guy has mastered the Eight Inner Gates. By opening the gates, his power grows by many folds. Guy's biggest moment came when he faced Madara Uchiha. No one was able to get close to Madara and no attack seemed to work. That's when Guy stepped up to the mark and opened the eighth and final gate. Guy was able to tear Madara's body into two with just one kick. Hashirama can't survive an attack as powerful as "Night Guy."
4 Obito Uchiha
Obito Uchiha's story is a very tragic one. He was used by Madara and Zetsu to fulfill their own wishes. Obito possessed the Mangekyou Sharingan that gave him the ability to make attacks just pass through his body. Obito became the jinchuriki of the Ten-Tails during the Fourth Great Ninja War. With the help of the truth-seeking balls, Obito was almost untouchable. Hashirama who was reanimated at that time clearly confirmed that Obito was way beyond his level. So, Hashirama himself knows that Obito is just too much even for a superb shinobi like him.
3 Hiruzen Sarutobi
Many Naruto fans don't rate Hiruzen at all. They don't think he's powerful enough to go up against the strongest shinobi, but they tend to forget that Hiruzen Sarutobi has the same epithet as Hashirama Senju. Hiruzen too was known as the "God of Shinobi." Hiruzen's knowledge about jutsu was far superior to any other shinobi. He even knew about the special jutsu of the clans in the Hidden Leaf. An old Hiruzen was able to face Orochimaru, and the reanimated First and Second Hokage (albeit they were not at full power). However, it must be kept in mind that Hiruzen wasn't at his prime either. He was able to neutralize Orochimaru's threat on his own.
2 Itachi Uchiha
Itachi Uchiha was a once in a generation prodigy. He was forced to be on the run after Danzo made him kill his own clan members including his parents. After the tragedy, Itachi joined Akatsuki in order to keep watch on them. Itachi was a victim of an unknown disease that eventually killed him. His real power was shown when he was reanimated and when he fought against Nagato and later against Kabuto. Itachi is arguably the best genjutsu user in the series and his Susanoo was called "invincible," by Zetsu. If Itachi is at full health then he can defeat Hashirama, but it won't be an easy job.
1 Hagoromo Otsutsuki
The final character on our list is the eldest son of Kaguya Otsutsuki, Hagoromo. Hagoromo was an insanely powerful character. He was the first character who awakened the Rinnegan. Hagoromo and his brother, Hamura, were responsible for sealing their mother after an insanely long battle. After sealing away their mother, Hagoromo became the jinchuriki of the Ten-Tails himself. So, his power increased even more. Also, he had an ability called the "Creation of All Things," which allowed him to create things out of nothing. There is only going to be one result when Hagoromo and Hashirama fight, and that is Hashirama's defeat.