As a respected member of Team Seven and the most formidable medical ninja in all of Konoha, Sakura has earned renown over the seven hundred Naruto episodes in which she has been featured. Her progression in physical strength reflects the development of her character.
Despite being the only of Kakashi's students not to receive Hagoromo's immense gifts, she nonetheless contributed to the battle against Kaguya, successfully wounding her with immense brawn alone. By analyzing those even more powerful than Haruno, we gain a more complete understanding of the strengths and weaknesses behind her abilities as a combatant.
10 All For One (My Hero Academia)
All For One may not have as much physical striking power as Sakura does, but he is able to win the fight in just one touch through the power of the quirk that shares his name. He would be able to steal her ninjutsu and incredible medical abilities at the same time, forcing her to rely on taijutsu to succeed.
In the unlikely event that Sakura should close the distance between them, the villain can also use his shock inversion quirk, reflecting the damage she intended to inflict back at her.
9 Shaiapouf (Hunter X Hunter)
Despite being the weakest of the Royal Guards, Shaiapouf would not need to rely on physical brawn or speed to defeat Sakura. When casting out his iridescent wings, he can produce a pollen which hypnotizes all that fall under its sway.
Given that Sakura has not shown notable proficiency combatting genjutsu (which has many similar properties), it stands the reason that this would render her a gibbering thrall, comfortably docile under the butterfly ant's charismatic spell. All he would need to do to avoid her is disperse into a dozen of tiny copies of himself.
8 Deidara (Naruto)
Deidara would encounter difficulty fighting Sakura because she is able to mend most of the damage he could hope to inflict against her. It would make it frustrating for him to secure a victory, even if he could keep his distance through his flying clay.
Like any true artist, the Akatsuki member is nothing if not resourceful. He could plant microscopic charges that crawl into Haruno's skin, detonating from the inside and killing her before she could hope to heal the damage dealt.
7 Diavolo (JoJo's Bizarre Adventure)
Diavolo's "Emperor Crimson" allows him to effectively erase the last ten seconds of time, able to move within the window that was lost. Through this technique, he was able to kill Narancia and would have ended Giorno if not for his unrivaled Golden Requiem Stand.
This would give him an opportunity to get in close to Sakura without risking being pummeled into oblivion. Diavolo's success is only compromised if he chooses to strike her stomach instead of her head, as the latter would be a wound that his shinobi adversary could recover from.
6 Barragan (Bleach)
The second most deadly of the Espada organization, Barragan is able to secrete a noxious fog that will progressively crawl up its host's body until it consumes them in their entirety. Only severing the compromised limb will prevent its progression.
It would make Sakura's endeavors in defeating him complicated, especially since his senesce naturally ebbs from his body. The closer the shinobi comes, the faster she disintegrates. Even throwing projectiles at him would crumble into nothingness before they could deal any damage, depriving Haruno of a much needed means of overcoming her undead adversary.
5 Zorin Blitz (Hellsing)
Much like Shaiapouf, Zorin Blitz would not rely on her comparatively unremarkable offense or durability to defeat Sakura in a fair confrontation. Instead, she would induce nightmares on the shinobi, forcing her to relive her most traumatic experience as she slowly encroaches for the killing blow.
So long as the Millennium agent targets her head instead of any of her organs, it would provide the necessary means of defeating her. Sakura may have a strong defense on account of her rejuvenation, but her durability leaves something to be desired and renders her vulnerable to such attacks.
4 Light Yagami (Death Note)
An excellent advantage behind the Death Note is that it slays its targets indefinitely, no matter how tough they might and disregarding their natural ability to heal. It would make Light's usage of it particularly effective against Sakura.
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Moreover, he's a talented liar, able to deceive the seasoned police officers dedicated to uncovering his identity for years. It would make it tangibly harder for Sakura to sniff out his intentions and allow him the chance to write down her name (which he would nonetheless be able to accomplish even against her wishes with enough distance, considering Sakura's average speed).
3 Derieri (Seven Deadly Sins)
Derieri's fighting style would give her a specific advantage against Sakura. With each swing of her claw, the power behind her attack grows exponentially stronger, and she is not prone to exhaustion.
As a result, anything that Sakura would be able to heal through (even with the seal on her forehead) would be unsustainable, as the Commandment's blows would exacerbate from bruising her arm to breaking it, and finally simply ripping it off. Once Haruno has been left vulnerable, the demon would able to rip out her soul by touching her.
2 Gilgamesh (Fate/Zero)
Gilgamesh might be vulnerable to Sakura's direct attacks, but his most comfortable theater is from the sidelines. He can create several arsenals of huge, golden weapons at a moment's notice, launching them with such impossible speed that even Iskander was not able to block them all.
It would be particularly difficult for Sakura if her arms are decapitated in this flurry, since she would not be able to weave hand signs. Such an inhibition would turn an already unlikely fight into one that was completely impossible for the medical ninja to win.
1 Gluttony (Fullmetal Alchemist)
Gluttony's chest is able to open and reveal a gate that swallows everything in its path. Considering that Sakura's first instinct to defeat him would be getting in close, this would catch her within its radius, swallowing her.
Not even Envy was able to escape its vacuum once it was activated from a distance, making it unlikely that Haruno would find any more success. Even if she was able to land a handful of devastating punches before being sucked in, the homunculus' finite ability to regenerate would ensure that he would survive the beating.