My Hero Academia's Quirk-based combat system has greatly expanded and evolved since the first episode, and not just in the variety of Quirks seen among caped pro heroes and the villains whom they fight. Quirks can be categorized in many ways, such as emitter types and mutation types, or even divided between support and direct assault Quirks.
A smaller and more informal Quirk category involves those that need extra fuel to function. Such Quirks consume an external, non-Quirk energy source to power up, and this sometimes has major implications on how those Quirks' wielders fight or even how they view themselves. Five particular Quirks stand out this way among heroes, villains and innocent bystanders alike.
Momo Yaoyorozu's Creation Quirk Consumes Lipids
The brilliant student hero Momo Yaoyorozu has the remarkable Creation Quirk, allowing her to create non-organic items from her bare skin. This may seem like an overpowered Quirk, but Momo isn't truly creating things from thin air. Her Creation Quirk consumes the lipids in her body to fuel that Quirk, effectively transmuting lipids into whatever item Momo wants to make. This means that she can only make so much material during a mission or battle, and overuse of Creation makes her skinny and frail. In the anime, Momo is usually seen eating a moderate amount of food, but during the forest training camp arc, Momo ate a huge quantity of food to power up her Quirk and rapidly make many items. Momo needed to exercise her Quirk all day long like a muscle, and that meant an endless stream of fresh calories to provide enough lipids.
One For All Is Ultimately an Energy-Stockpiling Quirk
At a glance, the unique One For All is a super-strength Quirk, and for secrecy's sake, that's what protagonist Izuku Midoriya let his teacher Shota Aizawa think at first. However, One For All isn't a muscle enhancement Quirk like Muscular's Pump Up is. Instead, its real purpose is to store charged energy, and over the decades and across nine users, One For All has become highly charged with powerful energy for Smash attacks.
Many years ago, a younger All For One granted this Quirk to his little brother Yoichi Shigaraki to help strengthen the latter's frail body. That, combined with Yoichi's undiscovered Quirk, created One For All -- an energy-based Quirk that can only be given willingly to another person. By now, Izuku can perform devastating Smash attacks and Shoot Style with that charged energy, making it a multi-component Quirk. Neito Momona learned that when he copied One For All, only to lack the stockpiled energy necessary to use it.
Eri's Rewind Quirk Needs Its Own Energy Source
The young Eri bears a powerful mutation Quirk called Rewind. With it, she can reverse another person's body to a previous state, potentially rewinding them to before they existed and thus erasing them from reality. The full potential of Rewind has yet to be explored, though Eri once used it to heal Izuku during the battle against Overhaul. More recently, Eri used Rewind to restore Mirio Togata's Permeation Quirk in the My Hero Academia manga. Like One For All, Rewind needs an energy source to function -- a mysterious source that's evidently only found in Eri's body. Neito Monoma copied Rewind, complete with the small horn, but he lacked the energy source to fuel it. For now, Rewind is Eri's unique ability, and no one can copy or steal it for their own use.
Bloodcurdle & Transform Both Require a Target's Blood
Two villain Quirks, Bloodcurdle and Transform, both require a gruesome fuel source to function: human blood. Bloodcurdle is Stain the hero killer's best weapon because once he ingests a target's blood, he can willingly paralyze them for a few moments. On its own, Bloodcurdle is practically harmless, but in practice, Stain uses it to finish off helpless pro heroes with his swords and knives. Stain usually uses his ragged katanas and knives to cut heroes in ambush attacks to obtain those much-needed blood samples, then uses the same weapons to finish the job once Bloodcurdle activates.
Meanwhile, Himiko Toga the trickster villain needs blood to fuel her Transform Quirk. She can only assume a given person's likeness when she has tasted at least a drop of their blood, and she can get blood samples with her knives or even with the needles on her villain costume. Himiko can evidently only use this on human targets; there's no sign that she can fuel her Quirk with animal blood to morph into a bird or rat, for example.