WARNING: The following article contains major spoilers for Marvel's Spider-Man on PlayStation 4.
Marvel's Spider-Man makes a lot of changes to established canon, with the most egregious example being at the very end of the game. It's been said that if Peter wins then Spider-Man has to lose, and the inverse is true as well. It just so happens this controversial loss went through its fair share of edits when developing the game.
After fighting a lengthy battle with Doctor Octopus, Peter is faced with giving his Aunt May the cure to the Devil's Breath plague that struck New York. May had spent the bulk of the game running the homeless shelter FEAST owned by Martin Li, aka Mister Negative, but fell ill of the Devil's Breath plague that struck in the game's third act. Spider-Man is given a choice: either May gets the cure or it's replicated to save the rest of the city. But May, having known her nephew was a superhero all along, tells him to use the cure to save everyone else afflicted at the cost of her own life.
Spider-Man voice actor/motion-capture performer Yuri Lowenthal talked at length about the game and the fun of being such an iconic character. When asked about that scene in particular, Lowenthal brought up that it was a plot point Marvel Comics initially pushed back on. "We can't have that," Lowenthal told The GameZone Podcast.
Though the scene itself had already been written and filmed between Lowenthal and May voice actor Nancy Linari, it was understandably something the company didn't want to have happen. Some months later as the game was continuing to be made, Marvel reversed their decision: "You guys have earned it, you can kill Aunt May," he said.
Lowenthal described the moment of (re)approval incredibly gratifying, and also something of a "roller coaster" for Linari to learn her character would be killed after all. Prior to the game's release, Insomniac Games showed him and the other actors the story's cutscenes put together like a cinematic film. He found the scene made him weepy, calling it one of the best moments of his lengthy career, and found it nice that so many people who told him they also teared up were men. Lowenthal even offered a way to bring May back for the eventual sequel, either in flashbacks or "Obi-Wan Kenobi style scenes."
Marvel's Spider-Man is out now on the PlayStation 4.