Eric Rupe gave me the following three key words: "Sci-Fi. Fantasy. Cyberpunk." He also wrote "My favorite comic writer is Grant Morrison so anything similar to his work is also something I'd be interested in."
I thought I should mention there are really two "go to" titles that everyone would think of first when trying to match up the categories of "cyberpunk" and "manga" -- Akira and Ghost in the Shell (both of which are now being re-issued by Kondansha Comics in the U.S.). But because these are the obvious titles, I'd thought I 'd recommend two titles slightly off the beaten path for Eric.
1. BLAME! by Tsutomu Nihei, published by Tokyopop.
Description by publisher: In a future world rife with decay and destruction, Killy is a man of few words who packs one very powerful gun. He wanders an endless labyrinth of cyberdungeons filled with concrete and steel, fighting off cyborgs and other bizarre silicate creatures. Everyone is searching for the Net Terminal Genes, but no one is quite certain what kind of power they contain. The answer may lie hidden among the scattered human settlements of this vast and desolate future world.
2. Clover, by CLAMP, published by DarkHorse (Omnibus edition).
Description by publisher: Kazuhiko is a young, but already deeply wounded black ops agent of a baroque, retro-tech future - pulled out of retirement to escort Sue, a mysterious waif, to a destination she alone knows. Sue and Kazuhiko have never met, yet she knows him, having grown up since the age of four with her only human contact, two distant voices: that of her elderly "grandma," General Ko, and of Kazuhiko's dead girlfriend, Ora. And Sue has been kept in that cage all these years because of what she is, and what the Clover Leaf Project found her to be - a military top secret, and the most dangerous person in the world!