Classic Marvel Comics villain Madame Hydra is coming to "Agents of S.H.I.E.L.D.," where she'll be played by an actress very familiar to viewers of the ABC drama.

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Entertainment Weekly unveiled the first look at the character, portrayed by none other than Mallory Jansen. Her introduction on Tuesday's episode, the series' return from winter hiatus, was screened Saturday at WonderCon Anaheim.

Malory Jansen

This marks the third role for Jansen since debuting earlier this season as the Life Model Decoy Aida, and then as Agnes Kitsworth, the terminally ill former love interest upon whom Dr. Radcliffe based the LMD.

With a new storyline taking place within the Framework, an alternate reality that explores what might have happened had Captain America not defeated Hydra in "Captain America: The Winter Soldier," the producers wanted to bring back the organization as "a forced to be reckoned with."

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“Madame Hydra is a villain with the perfect combo of strength, sexy, and scary," co-showrunners Jed Whedon and Maurissa Tancharoen told EW. "We’ve thrown many challenges Mallory’s way and she’s always up for the task. We’re excited for fans to see how she makes Madame Hydra come to life.”

Also known as Viper in Marvel comics, Madame Hydra was introduced by Jim Steranko in 1969's "Captain America" #110.

Returning Tuesday at 10 p.m. ET/PT on ABC, “Marvel’s Agents of S.H.I.E.L.D” stars Clark Gregg as Agent Phil Coulson, Chloe Bennet as Daisy “Quake” Johnson, Ming-Na Wen as Melinda May, Iain De Caestecker as Leo Fitz, Elizabeth Henstridge as Jemma Simmons and Henry Simmons as Alphonso “Mack” Mackenzie.