One of the most unforgettable scenes in Hiromu Araki’s JoJo’s Bizarre Adventure happened in 1987: Dio Brando, choosing to wear the Stone Mask and transform into the vampire, announces “I reject my humanity, JoJo.” A quarter-century later, the third episode of the 2012 anime adaptation recreated the moment for a whole new generation.

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As a result -- as with many iconic anime moments -- “I reject my humanity, JoJo” has become a prevalent meme, used best when depicting something that has nothing to do with JoJo’s Bizarre Adventure. So, with that in mind, let’s take a look at the best memes that play off of that.

10 Dio Is CeeLo

JoJo's Bizarre Adventure: Dio meme ceelo green

In 2017, singer CeeLo Green drew a lot of attention when he attended the Grammys dressed (basically) like a robot. It was meant to promote a new persona, “Gnarly Davidson,” but most viewers just wondered why he dressed up like C-3PO. More manga-oriented viewers, like the creator of this meme, decided to use CeeLo’s mask in the place of the Stone Mask, making for a solid Dio meme.

9 Dio VS Doctors

JoJo's Bizarre Adventure: Dio meme apple doctor

The anime adaptation of “I reject my humanity, JoJo” doesn’t seem to have the same verve or energy as the manga panel, which means you see it far less frequently in meme form than the black-and-white version. But you will occasionally see the animated version show up in memes, like this one. The joke is incredibly broad, based on the old cliche of “An apple a day keeps the doctor away,” but the use of Dio as a punchline makes it very funny.

8 Legend Of Dio

JoJo's Bizarre Adventure: Dio meme legend of zelda link

Other memes involve more specific references than old sayings about the value of eating fruit, like this online joke that combines JoJo’s Bizarre Adventure and the long-running Legend of Zelda series.

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In Legend of Zelda: Majora’s Mask, players have the ability to don various masks with different effects, including a Stone Mask, which allows Link to avoid detection when walking around an area. Of course, the mask that turned Dio into a vampire was also a Stone Mask, making for a pretty good joke.

7 Furry

JoJo's Bizarre Adventure: Dio meme wolf

If it weren’t for the internet, it’s likely that very few people would even know about furry culture. Besides being a curiosity for people who don’t bear an affinity for anthropomorphic animals, it’s also a go-to joke for many internet jokesters and meme makers. This meme is surprisingly not mean spirited as far as jokes about furries go, and instead uses the Dio meme to take the donning of a wolf mask very literally.

6 Paper Mache

JoJo's Bizarre Adventure: Dio meme paper mache mask with feet

A weird mask is always great fodder for a meme about Dio rejecting his humanity. This meme originated on Tumblr, as the curious image of a paper mache mask with feet was making the rounds on the website. One clever user decided to turn the mask into a Dio meme and subsequently went viral in the process. It’s unknown, however, where the mask came from, so maybe it does turn you into a vampire.

5 Super Smash Dio

JoJo's Bizarre Adventure: Dio meme super smash bros invitation

It’s impossible to turn down a great subversion of a meme, especially one that involves understanding multiple references. This one plays off of the character reveal trailers that Nintendo’s beloved Super Smash Bros. game has made famous, as they’ve frequently involved characters receiving invitations to go fight Captain Falcon, Jigglypuff, and company. The gag here, of course, is that rather than rejecting something, Dio Brando is accepting something.

4 Pickle Dio

JoJo's Bizarre Adventure: Dio meme pickle rick

Dio Brando isn’t the only cartoon character to transform into something that isn’t human. In Season 3 of the animated comedy, Rick & Morty, Rick turned himself into a Pickle, and the result was so popular that people turned to Pickle Rick fans before the show even aired.

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Over-explaining Pickle Rick has itself become a meme, so utilizing that joke as part of a Dio humanity meme without either character’s memetic catchphrase is a great creative decision.

3 Huge Manatee

JoJo's Bizarre Adventure: Dio meme huge manatee

Pronouncing “humanity” as “huge manatee” is a meme that goes all the way back to the late 2000s in the form of “Oh, the huge manatee,” playing off the infamous “Oh, the humanity!” as uttered by journalist Herbert Morrison during the 1937 Hindenburg disaster. Given that Dio says “I reject my humanity” in this iconic scene, the joke is obvious. This meme is especially funny because the text for “huge manatee” doesn’t match the rest of the word balloon.

2 The Great Pizza Debate

JoJo's Bizarre Adventure: Dio meme pineapple pizza

Despite the fact that everybody likes pizza, it’s often a source of some incredibly strong opinions. Along with the eternal New York vs. Chicago debate, there’s also a lot of controversy surrounding the use of pineapples as a topping. Some pizza eaters love pineapple, while others are disgusted by the idea of a sweet tropical fruit on top of a savory Italian dish. This meme, of course, takes the latter opinion about pineapples on pizza.

1 Shaggy Meme

JoJo's Bizarre Adventure: Dio meme shaggy vampire scooby doo

Remember when Shaggy from Scooby Doo was a meme? There was a whole fad involving memes about Shaggy having magical, godlike powers, making him perfect for the world of JoJo’s Bizarre Adventure. It got stale real quick, but this take on the Shaggy meme is pretty great. Rather than rely on the catchphrase, it only uses the iconic JoJo-styled katakana sound effects to draw a clever comparison of vampire Shaggy and Dio.

NEXT: JoJo's Bizarre Adventure: 5 Ways Dio Was An Excellent Villain (& 5 He Was Disappointing)