We've been hearing since at least the start of the year that Javier Bardem is up for the starring villain role in EON Productions' next, still-untitled Bond movie, which most just refer to for now as "Bond 23." The casting hasn't been confirmed in any official capacity since the talk first kicked up, but Bardem addressed the possibility personally in an appearance on ABC's Nightline (via MI-6).
In short, he's a lock. Bardem is our next Bond villain.
He wouldn't speak in specifics, although he did describe himself as "Bond's nemesis," adding, "but it's not that obvious. Everything is more nuanced. It's very intriguing. ... They're changing the whole thing, the whole dynamic." So ... that's non-specific. But awesome. Bardem gives great Bad Guy.