In both comics and the Marvel Cinematic Universe, Thanos massacred his way through the cosmos with his intentions squarely on assembling the most powerful weapon in existence: the Infinity Gauntlet. While the Infinity Gauntlets of the comic book and cinematic Marvel Universes are incredibly similar, the two Infinity Gauntlets possess two very different levels of power.
In each universe, the Infinity Gauntlet may be an unrivaled force of omnipotence, but the comic book Infinity Gauntlet is far more powerful than its cinematic counterpart in just about every way.
In both Jim Starlin, George Perez and Ron Lim's original The Infinity Gauntlet comic and Avengers: Infinity War, assembling the six Infinity Stones -- or Infinity Gems in the comics -- grants the wearer of the Gauntlet unprecedented control over the six different domains of those sources of power. From Reality to Space to Soul to Mind to Time to Power itself, the Gauntlet gives its wielder total control over the fundamental esoteric forces of the Marvel Universe.
However, the MCU seemed to have a slightly different definition of "total." The MCU's Infinity Gauntlet was defined by its limitations and the things it couldn't do as much as what it could do. In the MCU, the weapon relies heavily on its wearer making physical actions like closing a fist or snapping fingers. Throughout both Infinity War and Avengers: Endgame, the Avengers are able to stand a fighting chance against the Mad Titan by holding him off from accessing the powers within the Gauntlet.
On Titan in Avengers: Infinity War, the combined forces of Earth's heroes even nearly got the Gauntlet off of Thanos' hand, with Mantis incapacitating him mentally while everyone else pulled him in different directions. Even individually, the heroes were able to resist the villain's strength for brief stretches of time, with Doctor Strange's cloak and a piece of Iron Man's nanotechnology both effectively holding Thanos' fingers apart for a few moments. This proved to be a pretty major flaw that limits the seeming omnipotence of the weapon.
By comparison, the comics' Gauntlet never had that kind of limitation. Instead, its powers activated at the will of the wearer rather than through any physical motion. Quasar released a 100 megaton explosion between Thanos' ears to destroy him, but Thanos simply using the Gauntlet to reform himself afterward. Similarly, the Avengers released their attacks on him simultaneously, only to find the Time Stone froze repulsor beams and Mjolnir alike all in place. That simple freedom made the comics' Thanos a much more formidable force.
Beyond wiping out half of all life in the universe, the respective accomplishments of the two Infinity Gauntlets are at shockingly different levels. Outside of the Snap, the movie Thanos only used his Infinity Gauntlet to tear apart a Moon and turn back a piece of time to restore the Mind Stone.
Those accomplishments are nothing compared to what the comics Infinity Gauntlet accomplished. When Adam Warlock wears the Gauntlet, he was capable of juggling an entire galaxy. Thanos used the Space Gem to make multiple copies of himself, had the Power Gem to destroy a star and could use the Soul Gem to bring the dead back to life. That last instance touches on a particularly weak point of the film's iteration of the powers at play: the individual Stones were barely fleshed out, and the Soul Stone's power was never even really clearly defined.
By contrast, each individual Gem in the comics has its own history in hands of different wielders. Even a low-bit crook like the Hood became a universal threat once he began collecting the Gems for himself, and the Power Gem alone enabled him to go toe-to-toe with the Red Hulk in an all-out brawl. To a master wielder -- like Thanos -- who understands the intricacies of how the Infinity Gauntlet and all its component parts work, there truly seems to be no limit to what can be accomplished with an Infinity Gauntlet in its home universe.
In comics, the Infinity Gauntlet's only real limitation is that it can only be used in the reality it was created in. While that might mean an Infinity Gauntlet isn't much use in Marvel's multiversal multitude, it also means that the Infinity Gauntlets of comics and the MCU would not work in each other's universes. Based on what it accomplished in the comic book Marvel Universe, the original Infinity Gauntlet is capable of many, many more feats than the MCU's Infinity Gauntlet.