Square Enix revealed the first Marvel's Guardians of the Galaxy video game at E3 2021. While Square Enix hasn't announced many details about the plot, the trailer suggests that the titular team's lineup will be familiar to fans of the Marvel Cinematic Universe, which features Star-Lord, Gamora, Groot, Rocket, Drax and Mantis. At least two of the game's villains can be seen in the trailer lunging at Peter Quill. The two identical red brutes are the notorious Blood Brothers.
The Blood Brothers, Gh'Ree and R'hos, are Roclites from the planet Rocklon with super strength and super speed, who only become even stronger when they are close together. They first appeared in Jim Starlin, Mike Friedrich and Mike Esposito's Iron Man #55 in 1973, which also happens to be the first appearance of Drax. Thanos sends the two villainous aliens to capture Iron Man, who put up an admirable fight but was no match for their super strength. Luckily for Tony Stark, the Blood Bros take him to the same prison where Thanos is keeping Drax. He and Iron Man work together, and with the help of the Mentor, they are able to escape Thanos's clutches.
After his harrowing run-in with Thanos, Iron Man was on the hunt for Thanos's base of operations on Earth. When he found it in 1973's Marvel Feature #12 by Mike Friedrich, Jim Starlin and Joe Sinnott, Gh'Ree and R'hos were waiting for him. Thanos ordered them to kill the meddling hero once and for all. Tony once again struggled to match the speed and power of the terrible twins, but he manages to escape. He flies out of the base but crashes into the Thing, who happened to accidentally stumble upon the compound in the desert. While the two heroes were dazed from their collision, the Blood Brothers attacked, revealing themselves to be musclebound monsters are in fact "galactic vampires." Fortunately for Ben Grimm, their fangs are no match for his rocky exterior. Thing took advantage of their surprise and he and Iron Man worked together. The ensuing battle left Thanos's Earth base in ruins and rendered both brothers temporarily immobilized.
In his fury, Thanos uses his Cosmic Cube to zap the Blood Brothers to punish them for failing to defeat the heroes and protect his compound. It is initially unclear whether the brothers have been killed or merely transported elsewhere, but they reappeared years later in Archie Goodwin, George Tuska and Vince Colletta's Iron Man #88 in 1976. The brothers were back on Earth wreaking havoc for the Controller when they came across Iron Man again. After another fight, Stark once again sent the goons packing, this time with the help of Daredevil.
After another unsuccessful outing against Iron Man, the bloodthirsty twins have turned up here and there working for various Thanos-adjacent cosmic villains. They've been members of the Butcher Squadron and the Lethal Legion, but they've never really achieved much on their own. When numbers are in their favor, they are almost unbeatable, but whenever two heroes have a moment to strategize, the Blood Brothers are easily out-maneuvered. As intimidating as the two Roclites are, they are usually too hasty and overconfident to pose a long-lasting threat to any of their enemies.
The two seem like perfect villains for the Guardians of the Galaxy. After all, they debuted inthe same issue as Drax and have a decades-long history of working for some of the Guardians' most formidable foes. It is unlikely that they'll be the only bad-guys Star-Lord and company will have to fight, but they are sure to be engaging opponents.