WARNING: The following contains spoilers for Deadpool: Black, White and Blood #3, on sale now from Marvel Comics.
Ever since the team was first formed in New Mutants #100 (by Rob Liefeld, Fabian Nicieza, Brad Vancata, and Joe Rosen), X-Force has been defined by its more militant approach to protecting mutants. While the X-Men heroically battle evil in the spotlight, X-Force prefers to stick to the shadows, using intimidation, sabotage, and assassination to safeguard mutants from threats who use the same tactics, like the anti-mutant group Orchis.
One of X-Force's most iconic and effective members is the mutant Domino, who can complete missions that should otherwise be impossible thanks to her mutant ability to manipulate probability fields to give herself good fortune. However, Domino's uncanny luck may have just run out, as her recent assassination of Dr. Doom's cousin in Deadpool: Black, White and Blood #3's "The Bet" (by Frank Tieri, Takashi Okazaki, and Joe Sabino) might put her in the crosshairs of one of Marvel's deadliest supervillains.
"The Bet" opens with Deadpool and Daredevil's archenemy Bullseye massacring a horde of henchmen, with each putting their unique skills to work cutting down scores of men. It's soon revealed that each of them has been hired to kill Vincent "Vinny" Doom, a powerful crime lord who just so happens to be a distant cousin of Victor von Doom. Racing each other to get to Vinny first, the accomplished assassins face off against an army of ninjas, a horde of zombies, a school of sharks with laser beams attached to their heads, and a room full of murderous monkeys. Eventually, Deadpool manages to get to Vinny's office before Bullseye, only to discover that Domino has already completed the mission. When Deadpool demands to know how she got through Vinny's defenses before them, she reveals that she slipped into his office through an unguarded backdoor.
Domino doesn't take the time to explain why she killed Vinny to Deadpool before she escapes through an open window, leaving her motivations a mystery. While Domino is known for her affiliation with X-Force, she also has a very accomplished side-career as a freelance mercenary. The cousin of Doom likely had many enemies, and any one of them could have hired Domino to kill him. Or, if this was an official X-Force operation, perhaps Vinny's illegal activities were somehow affecting mutants. Regardless of her reasons, the consequences of Domino's successful assassination might be more than her luck-bending power can handle.
Dr. Doom has never been particularly fond of mutants, but he's also never gone out of his way to harm them. However, ever since Charles Xavier, Moira Mactaggart, and Magneto formed the mutant nation of Krakoa, Dr. Doom's opinion of mutants has taken a turn for the worse. Doom's interaction with Xavier in X-Men/Fantastic Four #3 (by Chip Zdarsky and Terry Dodson) shows that the ruler of Latveria finds Xavier's assertion that mutants are superior to humans distasteful. Doom even goes so far as to challenge Xavier by asking him if a mutant born with their powers is truly better than a human who worked to acquire the knowledge and talent needed to reproduce those same powers through technology or magic. While Doom does show Xavier respect, his words make it clear that he has no intention of allowing Krakoa to assert superiority over him.
While there is a slim chance that Doom didn't have any affection for his cousin, Doom tends to see any act of aggression taken against people or places even remotely associated with him as a personal slight. If Domino's assassination of Vinny was an X-Force mission, then it was likely carried out by order of the Quiet Council, which could give Dr. Doom an adequate excuse to move against the mutant nation. And if it wasn't, then Domino herself could very easily become the sole focus of Dr. Doom's wrath.
The tension between Latveria and Krakoa has been building for some time, and Domino's actions could plunge the two nations into an all-out war. If this happens, Domino's ability to overcome the odds might be the only thing that can save her and Krakoa from Dr. Doom.