Disney+ in Brazil, among other select non-U.S. markets, has moved Agents of S.H.I.E.L.D. from the Marvel Cinematic Universe section to "Marvel Legacy," suggesting the show is no longer fully MCU canon.
As noted by the Reddit user who caught this, Disney+ has also moved ABC's other Marvel TV shows to the "Marvel Legacy Movies and Series" section in these markets, along with Hulu's Runaways. This further indicates the various live-action series developed by the now-defunct Marvel Television -- including, Marvel and Netflix's Defenders titles -- are no longer regarded as being strictly in the MCU continuity.
Show-run by Jed Whedon and Maurissa Tancharoen, Agents of S.H.I.E.L.D. followed Phil Coulson after his sorta-death in 2012's The Avengers, along the way bringing Marvel comic book superheroes like Daisy Johnson/Quake into live-action for the first time. But while Agents of S.H.I.E.L.D. started off trying to interconnect with the MCU's films, even featuring appearances from characters like Nick Fury and Sif, the show began to increasingly drift away from the events of the franchise's Infinity Saga in later seasons.
This can largely be attributed to the schism between Marvel's TV and movie divisions, prior to being folded together under Marvel Studios President and Marvel Chief Creative Officer Kevin Feige's leadership in 2019. Clark Gregg, who first played Coulson in 2008's Iron Man, talked about this in a May 2020 interview. "You know, no one ever knew [Agents of S.H.I.E.L.D.] would go [to] 130-some episodes," he said. "It was never going to be like, this week Tony Stark is here!"
"Then there was the division between Marvel TV and Marvel Cinematic on a corporate level," he added. "So the showrunners, Jed [Whedon] and Mo [Tancharoen] and Jeff Bell, had to really scour parts of the Marvel universe that weren't tied up with the incredibly elaborate plans of the cinematic [universe]. They ended up using all kinds of things: Inhumans, time travel, Ghost Rider, all these things that nobody is using, and many times to great effect."
Because of this, Agents of S.H.I.E.L.D. more or less deviated entirely from the MCU's timeline in its final two seasons, ignoring the events of Avengers: Infinity War and Endgame. This has also led to fan theories about the ways Agents of S.H.I.E.L.D. created its own timeline prior to its time-traveling Season 7, providing an in-canon explanation for why the TV show went the direction it did.
Source: Reddit