That's right-if you add together all the Deadpool series (creatively) issue 45 is the big 250th issue of Deadpool! What better way to celebrate than to end the series? In our over-sized main story, ULTIMATUM comes at Deadpool for revenge, so he has no choice but to take them on-ALL OF THEM. Then, in an Infinity Gauntlet crossover, what would Deadpool do if he got the six gems from Thanos? Plus: a slew of stories showcasing Deadpool's closest friends and allies by special guest writers! Also, SPOILER: Deadpool dies at the end of the issue.