Deadpool 2 director David Leitch says that there is a connection between Deadpool's X-Force and the X-Men of the X-Men movie universe.
In an interview with Fandango, Leitch discussed the different methodologies the two teams use. As the director explains it, X-Force "have their own sort of code. There's a real defining line between what's right and wrong, and how to get things done, and sometimes things are gray and you have to fight dirty." While the X-Men sit on the right side of the law, "X-Force is leaned into a little bit more of the amoral code, like Deadpool."
This sentiment seems to be in line with the Rob Liefeld's own view of the team, which he recently revealed in a similar interview. Liefeld saw that "You had pacifist [X-Men] and terrorist [Magneto], and I introduced a much more aggressive arm of the X-Men.” They may be the good guys, but they are far more aggressive and amoral than Xavier's squad.
As for whether or not X-Force will interact with the X-Men and the greater universe at large, Leitch did tease what to expect. "Yeah, [Deadpool is] part of the X-Men lore. We did find some natural tie-ins, and I think it's really going to be fun." The most recent trailer revealed that the X-Mansion and Blackbird will be seen in the film, hopefully expanding on some of the glimpses we received in Deadpool.
Directed by David Leitch, Deadpool 2 features Ryan Reynolds as Deadpool, Brianna Hildebrand as Negasonic Teenage Warhead, Leslie Uggams as Blind Al, Stefan Kapičić as the voice of Colossus, and Karan Soni as Dopinder, with newcomers Zazie Beetz as Domino, Josh Brolin as Cable, Julian Dennison in an unknown role and Jack Kesy as a villain widely thought to be Black Tom Cassidy. The film hits theaters on May 18.