If early box office projections hold true, then Deadpool's second coming is bound to be bigger than the first.

According to Variety, Deadpool 2 is on track to earn $150 million domestically in its opening weekend, surpassing the $132 million debut of the 2016 original. That film ultimately raked in $783 million worldwide, becoming the highest-grossing R-rated release in history.

RELATED: Deadpool 2 Breaks Record For Regal Cinemas Advance Ticket Sales

Fox's Deadpool 2 arrives in theaters May 18, three weeks after Marvel's Avengers: Infinity War, which is on a path to grossing between $225 million and $245 million this weekend in its North American debut. It's possible Infinity War could surpass 2015's Star Wars: The Force Awakens to claim the biggest opening weekend of all time.

Starring Ryan Reynolds, Deadpool 2 follows the Merc With a Mouth as he assembles his own team of heroes, X-Force, to protect a young mutant from Cable.

RELATED: Deadpool 2 Final Trailer's Best Moments & Biggest Questions

Directed by David Leitch, Deadpool 2 features Ryan Reynolds as Deadpool, Brianna Hildebrand as Negasonic Teenage Warhead, Leslie Uggams as Blind Al, Stefan Kapičić as the voice of Colossus, and Karan Soni as Dopinder, with newcomers Zazie Beetz as Domino, Josh Brolin as Cable and Julian Dennison as Russell. The film hits theaters on May 18.