WARNING: The following contains spoilers for Batman: The Knight #1, on sale now from DC Comics
Bruce Wayne has suffered from all sorts of internal conflicts and hang-ups over the years. These personal battles have often complicated his work as Batman. That said, without them, he'd likely lack the drive to actually ever become the Dark Knight. That doesn't make them necessarily strengths though. In fact, his greatest villains have a tendency to target them, and rightfully so.
Batman: The Knight #1 (by Chip Zdarsky, Carmine Di Giandomenico, Ivan Plascencia, and Pat Brosseau) continued the tradition of Batman's greatest foes attacking his psyche above all else. The story gives a new origin story a thematic tie to Batman's cinematic counterparts, and it also highlighted why this is the best way to target Batman.
Batman: The Knight is just the latest attempt to explore the early days of Batman. Like many others, Batman: The Knight revealed that many of Bruce's earliest challenges were psychological in nature. Specifically, he found himself confronting Hugo Strange. Posing as a psychiatrist who in reality steals the funds of his patients, Strange attempted to psychoanalyze Bruce to gain an advantage over him. Bruce, seeing through Hugo's act and already altering the police to his crime, used it as an opportunity to look back at his own growth. It's an interesting premise, and likely a psychological attack is one of the only ways to really defeat Batman in the past or present.
Thanks to his litany of skills and weapons, Batman is almost impossible to defeat in a fight. Likewise, his incredible mind makes it difficult to ever get ahead of the Dark Knight in challenges. But his greatest weakness has always been the same inner strength and turmoil he relies on to fuel his war on crime. Batman's psyche has been targeted by multiple villains over the years, especially by the likes of Hugo Strange. It's these psychological attacks that often have the best chance of actually affecting Batman and doing damage to him. Some of Bruce's greatest challenges have come when enemies target his mind (like in Batman: R.I.P by Grant Morrison and Tony Daniel). The Hugo Strange of Batman: The Knight was a good indicator of just how much of an obvious target it really is.
It's also a tactic taken by some of Batman's best enemies outside of the comics. In films like The Dark Knight, the Joker was never under the illusion he's going to kill Batman or beat him in a fight. Joker targeted Batman's spirit and psyche instead. He attempted to break Batman's mind in a more deliberate and enduring way rather than his body. It's also seemingly the modus operandi for the Riddler set to be featured in the upcoming film, The Batman. The Riddler has been clearly shown in the trailers as a master manipulator, playing out some twisted game with Batman that likely plays more on his psychological weaknesses rather than directly confront him.
While Batman: The Knight illustrated how difficult it is to break Bruce's mind even when he is relatively untrained, it remains a valuable way to deal with Batman. It gives characters like Hugo Strange, Joker, and Riddler, all relatively human threats on a physical level, a greater chance to actually defeat Batman. It's also perhaps the best way to actually target Batman, utilizing his many flaws to their advantage. By ignoring the obvious means of confronting Batman on a physical level, his greatest cinematic foes (and some comics enemies, like Hugo Strange) have found his ultimate weakness.