ABC has debuted the first clip from the Season 4 premiere of "Marvel's Agents of S.H.I.E.L.D.," in which Melinda May calls in agents Coulson and Mackenzie after six weeks aboard the Zephyr to investigate something "odd."

After an exchange of pleasantries, May reveals there were two murders in Los Angeles, and based on the evidence, Quake, aka Daisy, may be involved. While she knows Coulson and Mack have been forbidden from pursuing Daisy, she agrees to buy them some time to investigate on their own.

The scene ends with opinion split on whether or Daisy's motivations are still heroic. Although Mack and Coulson are worried the government will "do something bad" to Daisy that's undeserved, May is concerned Daisy will "do something worse."

“In light of the Sokovia Accords, and with Hydra obliterated, S.H.I.E.L.D. has been legitimized again and no longer needs to operate in the shadows. Since the world presumes that Coulson is dead, the organization needed a new Director to be the face of the organization. Coulson finds himself back in the role as an agent and teamed with Mack, and together they are tasked with tracking down and confirming the presence of Enhanced people, aka Inhumans. They have been trying to track down and capture Daisy, aka Quake, who has gone rogue in an attempt to atone for sins from the past. But with the world believing that Daisy is a dangerous outlaw who has taken down banks and bridges, the new Director has no qualms about taking her down for good. Agent May is tasked with training specialist strike teams, and Fitz and Simmons have taken a big step forward in their relationship. But with Simmons’ new promotion as Special Advisor to the Director in Science and Technology, Fitz, as well as her former team members, finds it hard to confide in or trust her since she’s now the Director’s confidant.”

"Agents of S.H.I.E.L.D." returns for its fourth season Tuesday at 10 p.m. ET/PT on ABC with the episode "The Ghost." Returning stars

Clark Gregg, Ming-Na Wen, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge and Henry Simmons are joined this season by Gabriel Luna as Robbie Reyes, aka Ghost Rider, and Jason O'Mara as the new director of S.H.I.E.L.D.