Midway through the trailer for Avengers: Endgame, there is a shot of Thanos walking through a field, with the Infinity Gauntlet still stuck -- almost fused -- to his hand, heavily damaged from its massive exertion of power at the end of Avengers: Infinity War, when Thanos used it to kill off half of all living creatures in the universe.
Joe and Anthony Russo, the directors of Avengers: Endgame (as well as Avengers: Infinity War, part one of this epic storyline) confirmed in their commentary for Infinity War that "using the Gauntlet for such an act took its toll on Thanos, and the Mad Titan will remain permanently damaged because of it. This makes sense, considering the massive levels of power the villain was wielding. Furthermore, with the Gauntlet damaged, there might be no easy fix to the snap."
This leads to the obvious question: Can the Infinity Gauntlet actually be destroyed?
Here is the biggest problem with any sort of theory regarding the Infinity Gauntlet, whether it be the comic book version or the Marvel Cinematic Universe version: up until the crossover event, Infinity Gauntlet, there literally was no Infinity Gauntlet.
What we mean by this is that the cosmic artifact that we now know as the Infinity Gauntlet was simply one of the gauntlets that Thanos had been wearing in the comics for years, but with Infinity Stones (called Infinity Gems originally in the comics) placed on to it.
Here is Thanos with his gauntlets from his first appearance in the pages of Captain Marvel (the true beginning of Jim Starlin's decade-long exploration into Thanos' quest for power)
Here, then, is Thanos with the Infinity Gauntlet...
See? It's just his own gauntlet with Infinity Stones stuck on them. When you have a set-up like that, it essentially tells you there really are no stringent set of rules that the Gauntlet is playing by in the comics.
In fact, the only true "rule" we ever got regarding the Infinity Gauntlet was alluded to in Warlock and the Infinity Watch #1, then confirmed in Infinity War, which is that The Living Tribunal (one of the most powerful cosmic beings in the universe) ruled that the Infinity Gems could never be combined together to form the Infinity Gauntlet. The Tribunal made an exception when Eternity, the cosmic being who made the original petition for such a ruling, allowed an exception. In The Infinity War #6 (by Jim Starlin, Ron Lim and Al Milgrom), that exception was permanently rescinded.
However, that "permanent" rule was not followed, as the Infinity Gauntlet has been used numerous times since. In other words, all bets are off when it comes to the Infinity Gauntlet.
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