WARNING: The following article contains major spoilers for Boruto: Naruto Next Generations #38 by Masashi Kishimoto, Mikio Ikemoto and Ukyo Kodachi, on sale now.
In the Naruto Universe, Uchiha Sasuke has only really been defeated by one person: Naruto himself. The fight against his brother, Itachi, was more or less thrown as Itachi wanted to power Sasuke up, and also because he was dying from a mysterious disease and needed his younger brother to carry on his clan name and restore its honor.
This gave rise to a Sasuke who was now ready to master all the powers of the Uchiha. Still, when Naruto beat Sasuke, it came down to a fist fight as both teens knew how to counter each other's moves. That said, as seen in the battle against Kaguya, it seemed like no one could really nullify Sasuke's abilities and he was on course to become a legend as predicted by the Sage of the Six Paths.
Well, the notion of Sasuke boasting unstoppable weapons has changed drastically in the Boruto manga, all thanks to Jigen disarming the ninja with ease.
This chapter reveals Jigen is merely a vessel being used by the unknown Isshiki Ōtsutsuki. He wants to drain all chakra from the world and takes Naruto to a hidden dimension where Sasuke luckily tracks them to. The two Konoha ninjas then brawl with Isshiki's host but with Naruto and his Nine Tails Fox, Kurama, struggling as Isshiki absorbs their chakra, Sasuke's the real hope in the scrap thanks to his Rinnegan which allows him to teleport away from Isshiki's shrinking chakra-draining rods as much as possible.
However, when Sasuke throws his first big volley, it has no effect. This comes in the form of the Susanoo, a chakra golem similar to the Jaegers from Pacific Rim, which forms over the talented members of the Uchiha clan. Each has a different Susanoo, which acts as a giant warrior made from mystical energy, with the host inside controlling it. Sasuke's is tremendously powerful and one of the strongest ever in the franchise, but Isshiki easily absorbs its blows and then smashes through it, sending Sasuke hurtling to the ground, leaving him badly damaged.
Naruto is stunned because not even he could penetrate the Susanoo like this. Sasuke has no answer as this weapon is something Itachi, Obito and Madara all used in the past to great effect. Isshiki, though, laughs it off and makes it clear the Susanoo is child's play.
Needing another Hail Mary after being battered with Naruto, Sasuke uses a last resort move and deploys the Amaterasu, or "Infinite Flame," to try to burn Isshiki up. Shot from his eye, this move consumes its target with black flames which will burn forever until the victim dies, and it's one that doesn't miss at all. Once you're picked, you're effectively dead, and it's something Sasuke perfected thanks to Itachi's tutelage. Sadly, this move is also brushed off by Isshiki, who absorbs the energy as if it were ordinary chakra.
Sasuke's speechless because the Amaterasu is also one of the most powerful weapons in shinobi history, and with Naruto struggling to come up with new tactics and move-sets, Sasuke is left wondering what else can be done against such a godlike enemy. Isshiki isn't scratched by these weapons, although he does expend enormous amounts of chakra fighting the heroic ninjas off in hand-to-hand combat -- the only strength they have against him.
Still, by the time Naruto is sealed away, Sasuke -- who's nearly mortally wounded -- has to retreat to come up with a Plan B. Luckily, his Rinnegan teleports him to Konoha and his wife, Sakura, but he knows deep down hope may be lost. He and Naruto couldn't cut it and with the Hokage now missing in action, a weakened Sasuke is left petrified over the thought of taking other allies to battle Jigen's puppet master.
Boruto #38 will be released on Oct. 20.