Boruto Next Generation follows the story of Boruto Uzumaki and his Team 7 teammates, Sarada Uchiha, and Mutsuki (clone son of Orochimaru). So far, they've journeyed through the Ninja Academy and have graduated to the level of Genin. All three ninjas are seen as promising young Shinobi, who could one day lead the Village Hidden in the Leaves.
They've all shown tremendous levels of chakra control and can change its nature to perform devastating Jutsu. This list will point out some characters from Boruto who could take over from Naruto as Hokage and some who just aren't suited for the job.
10 Can: Shikamaru Nara
Shikamaru is currently an assistant to the 7th Hokage, Naruto Uzumaki. The two have known each other since they were young and can both be considered exceptionally strong ninjas.
Though not as physically strong as a character of Naruto's level, Shikamaru greatly makes up for this through being exceptionally smart. Shikamaru can read dozens of steps ahead of his opponents, making him a tricky combatant. His Shadow Possession Jutsu can also be a tricky thing to face. He also displays exceptional leadership skills and has led his generation of Ino-Shika-Cho to many victories, so he is a suitable candidate who could replace Naruto as Hokage.
9 Can't: Kawaki
Kawaki is a young man determined to end the era of the Shinobi and usher in a new era more in line with his principles. Though not much is currently known of his philosophy, it can be assumed to be pretty important based on how far Kawaki was willing to go to achieve it.
Kawaki was willing to destroy a significant part of the Leaf Village in order to get to his goal. This shows a sense of ruthlessness that could unnecessarily endanger innocent lives. Though Kawaki is indeed strong and intelligent, his moral alignment is wrong, meaning he would not be a suitable candidate to replace Naruto.
8 Can: Konohumara Sarutobi
Konohamaru is a Jonin currently in charge of Konoha's Team 7 where he oversees the development and training of Boruto Uzumaki, Sarada Uchiha, and Mitsuki. He harbors ambitions of one day becoming a Hokage, much like his friend and hero, Naruto Uzumaki. Konohamaru learned the Rasengan from Naruto and it is currently the strongest Jutsu at his disposal. Konohamaru's strength and determination mean that he'll continue to grow stronger, meaning one day he could possibly achieve his dream.
7 Can't: Metal Lee
Metal Lee is the son of Rock Lee and is currently a genin of the Leaf Village. Metal Lee is a dedicated and hard-working shinobi just like his father, which has so far greatly aided his development as a ninja. Unlike his father, Metal suffers from performance anxiety, which makes it incredibly hard for him to perform his duties at times. Outside of his anxiety attacks, Metal shows the potential to become a strong ninja. Yet, until he sees a therapist, he should be kept away from the battlefield.
6 Can: Boruto Uzumaki
Boruto Uzumaki is the son of history's strongest ever ninja, Naruto Uzumaki. Boruto is a child prodigy who can master complex techniques, and, even at his young age, he managed to use the Rasengan. Boruto is capable of applying several different nature transformations to chakra, a technique even some Jonin are incapable of.
He is loyal and committed to his friends, which could lead to him one day becoming an exceptional leader. If one takes that into consideration, along with his Kama and Jogan, it's clear to see why Boruto, just like his father, could one day become Hokage.
5 Can't: Mitsuki
Mitsuki is a partial clone of Orochimaru, meaning he has the potential to grow into one of the strongest characters in the series. Orochimaru was as cunning as he was strong, and that led to him becoming one of the most wanted criminals ever. With Orochimaru having designed Mitsuki himself, Mitsuki is sure to have incredible potential.
So far, he's been capable of performing Sage Mode, despite only being a Genin. In this form, he displays incredible chakra control, making him faster and stronger. Much like his father, Mitsuki can also be clever and undoubtedly has the talent it takes to one day reach the level of Hokage. But, even then, Mitsuki would rather see Boruto or Sarada take the title.
4 Can: Sarada Uchiha
Sarada is a member of Team 7 under the leadership of Konohamaru Sarutobi and a member of the Leaf Village's Uchiha Clan. Sarada is the daughter of Sasuke Uchiha and Sakura Haruno, two of the village's strongest Shinobi.
Sarada is a perceptive, young kunoichi who regularly outsmarts her peers and, at times, adults. Sarada is capable of using multiple forms of nature transformations to defeat her foes, with her expertise lying in Fire and Lightning Releases. This, combined with her Sharingan, marks her as a young ninja with immense potential—a potential that will one day lead her to her dream of becoming Hokage.
3 Can't: Shino Aburame
Shino Aburame is the current head teacher at the Leaf Village's Ninja Academy, where he does his best to impart wisdom to his pupils. Shino has become far more experienced in dealing with people, which greatly aids his transition into his new role.
His excellent insect-based Jutsu makes him an exceptional ninja, and his intellect has led to many victories against tough opponents. Despite this, Shino does not yet have a commanding enough presence to be able to fill the role of Hokage.
2 SASUKE UCHIHA (CAN) Can: Sasuke Uchiha
Sasuke Uchiha is one of the two strongest ninjas to ever exist in Naruto. Decades of training molded his mind into one ideal for carrying out the missions of a Shinobi. Sasuke was shown to be skilled from a young age, but, no matter how skilled he was, he always craved even more strength.
This eventually led him down a dark and lonely path, but he was rescued from this seclusion by his friend and rival, Naruto. Sasuke is strong and intelligent and should Naruto ever step down, he should be the Leaf Village's number one candidate.
1 Can't: Orochimaru
Orochimaru is one of the Legendary Sannin, a group consisting of Jiraiya, Tsunade, and Orochimaru, who were considered three of the strongest ninjas of their time. A curious and troubled ninja from his youth, Orochimaru would one day take his experiments too far and had to flee from his village.
As a criminal, Orochimaru perpetrated many heinous acts against the Leaf Village as a means to gain revenge for them expelling him. This alone means there is zero chance of him ascending to the position of Hokage.