What's better? To be technologically indestructible, or biologically immortal? I guess in the context of never meeting your demise, there's not a difference and you walk the primrose path to living forever. However, such is not the case in the realm of comic books, where the power and intelligence rankings are found in the details.
One's an outrageous bounty hunter with strength on par with Superman and is unforgiving in his hunt to apprehend if you're his target. While the other is a government experiment gone wrong, but wrong for all the right reasons, avenging those taken by his captors. Bloodshot & Lobo are understood as anti-heroes but there's plenty of interesting things that separate the two extreme characters.
10 Lobo - Twisted Origin
Making himself the last surviving member of his species, the Czarnians, Lobo became the first in his race that displayed evil intent in 10 millennia when as an infant he drove his caretaker insane by biting off her fingers. Lobo, in the Khund dialect, means "he who devours your entrails and thoroughly enjoys it." This monster hails from a planet of near-immortal beings, who never fretted war, but is completely wiped out by Lobo when he sends a swarm of scorpion-like creatures on his people in the name of it being a science project. Demented? Yes. Awesome? Double Yes.
9 Bloodshot - Cloaked Origin
An experiment of the government agency Project Rising Spirit, the man/machine known as Bloodshot believes himself to be Raymond Garrison, a military-trained soldier, or maybe it's Angelo Mortalli, a mobster who curtailed to the officials and paid the price for doing so. With a back story very akin to that of The Joker, in the way of having no definitive origin, Bloodshot is brainwashed by nanites, that have implanted conflicting memories of different lives into his mind. This journey of perplexity for both the reader and character gave way of Bloodshot's history being mired in mystery.
8 Lobo - Regenerative Healing Factor
Believed to have one of the most rambunctious healing factors in all of comics, exceeding the likes of Wolverine & Deadpool, the healing factor of Lobo has caveats that make him an immortal pain in the superheroes backside.
The first is being barred from entering Heaven or Hell, as well as his natural physiology and the belief that only a Czarnian is truly capable of killing another Czarnian. Once healing himself from a pool of his own blood, and even creating duplicates of himself with droplets of blood through a process called bio-fission, Lobo is inextinguishable in every sense of the word.
7 Bloodshot - Nanite Technology
The "healing factor" of Bloodshot is, in fact, microscopic machinery created by Project Rising Spirit. The technology came to be known as the Blood of Heroes and would go on to be imbued in the 41st century to a warrior named Takao Konishi, 43rd in the line of Rai. Beyond a healing factor, the nanites also provide super strength, speed, and agility with local tech being overridden by his technopathic abilities. His only provision being he must consume protein to stay replenished, otherwise the nanites will be ill-sufficient in safeguarding his regeneration.
6 Lobo - Wolverine Parody
While it's a well-known fact that there is a give and take between the Marvel and DC publishing houses, it's almost unheard of when the character's creator comes out and admits he was explicitly created to be a parody on an existing character. There was Marvel's Deadpool and DC's Deathstroke, as well as Man-Thing and Swamp-Thing respectively, but in this case, it was the outrageousness of Marvel's Wolverine that manifested Lobo into the gritty, high-octane, and potty-mouthed space biker that fans unexpectedly couldn't get enough of.
5 Bloodshot - Wolverine Inspiration
In the context of complicated yet intriguing character developments, Bloodshot shares much inspiration of the concept with James Howlett, better referred to as Logan or his alias Wolverine. Tricked by a government agency to carry out missions in false consciousness and eliminate psiots, a suspected looming threat of psionic enhanced sub-humans also called Harbingers, "Raymond" would come to learn the truth when Kuretich, a member of Project Rising Spirit, reprogrammed his nanites to remove the veil behind the lies of his life.
Trying to now repent and be his own man, it is speculated that Bloodshot himself is a psiot and thus was capable of surviving the Bloodshot experiment, as opposed to the previous human trials that proved unsuccessful. The hues of similarity are pretty apparent and are supposed to serve as an inspiration and not a rip-off, at least not blatantly, however that's in the eye of the reader.
4 Lobo - Apathetic Incarnations
Introduced in June of 1983 by Keith Griffin and Robert Slifer, Lobo's first appearance was in Omega Men #3. In the pre-crisis era, he was originally referred to as a Velorpian, an overpopulated race of violent conquerors wiped out by the Psions, an advanced reptilian-like species, leaving Lobo the lone survivor. However, it would be the character's reinvigorating retcon in 1990 by Alan Grant and Simon Bisley that would see the outlandish and eccentric Lobo, we're most familiar with today, begin to receive universal acceptance. Unfortunately, the New 52 incarnation of Lobo would come to be widely despised by the fan base, even being dubbed "Twilight Lobo" due to the sleek and polished depiction of the character, being a complete 180 from the Lobo fans loved.
3 Bloodshot - Intriguing "Memories"
Bloodshot's mythos has had a culmination of many writers and artist since his inception, but his introduction came as a cameo in 1992's Eternal Warrior #4, before making his full appearance in Rai #0. Created by Kevin VanHook, Bob Layton, and Don Perlin, he was initially a mobster making his way through the ranks until he's framed for the murder of a rival gangster due to him being disloyal to the boss's daughter. Cutting a deal with the FBI to act against the Mob, Angelo's old boss catches wind of his betrayal and is eventually roped into a Japanese program named Musashi Labs, better known as Project Rising Spirit, who specializes in experimental weaponry.
Another iteration saw Bloodshot introduced as a military-trained fighter named Raymond Garrison. Killed in a terrorist attack trying to protect his family, his body was donated by the military to Project Rising Spirit, this time a government agency, who imbued him with nanotechnology and resurrected him. While Bloodshot feels a strong connection to his "Raymond" life, its speculated both his military and mobster lives are just two of the many "memories" implanted in his head, provoking some unanswered questions about his history.
2 Lobo - Zany Anti-Hero
While being inspired by the shocking and over the top antics of the 1980 and 1990 comic book landscape, as stated before, Lobo was a satire character, introduced as a means to make a mockery of the current era. However, fans reveled in the concept of what came to be known as the Main Man. Commonly a foe of Superman and the Green Lantern Corps, the intergalactic bounty hunter would join the heroes in the 2017 Justice League Vs. Suicide Squad crossover that ultimately saw Maxwell Lord use the Eclipso Diamond to take control of the Justice League. This leads Batman to initiate a new Justice League to combat Lord's forces, this new league consisted of villains previously part of the Suicide Squad such as Killer Frost, Killer Croc, Deathstroke, Harley Quinn, and Lobo himself. Lending defeat to Maxwell Lord, he should've known better than to leave Batman as an open variable.
1 Bloodshot - Misunderstood Anti-Hero
Borrowing a few concepts from established characters such as Wolverine and The Punisher, the unrelenting violence paired with technologic amnesia makes Bloodshot one of the most misinterpreted characters in all of comics. It remains unclear whether his barbaric brutality is a result of the nanite programming or an innate characteristic that is amplified by the nanites. However, "Raymond" does feel remorse for his past actions when he finally comes to realize the truth of his manipulations. He seeks to be solely a man at peace with his freedom and not a mindless killing machine, whether it be under the influence of Project Rising Spirit, or the Harbinger Foundation, a psiot led organization, believing both to just be two sides of the same coin.