WARNING: The following contains spoilers for Darkhold: Blade #1, on sale now from Marvel Comics.
Darkhold: Blade (by Daniel Kibblesmith, Federico Sabbatini, Rico Renzi, and VC's Clayton Clowles) has officially brought several key plot points from the original Blade film into Marvel canon. The one-shot Darkhold: Blade introduces readers to a world where all mutants, inhuman and superhumans have been transformed into either humans or vampires. Now it's the fanged versus the food in a dystopian nightmare that acts as a perfect What If...? scenario that reflects Marvel's original Blade movie starring Wesley Snipes.
1998's Blade was all about Marvel's Daywalker coming to terms with his vampiric affliction while hunting down Deacon Frost, who leads a group of vampires and wants to start a war with the human race. The elders are of pure blood and look down on Frost because he was turned through being bitten. Deacon takes offense to this so he kills one of the elders and kidnaps the rest. He leads a mutiny against the pureblood vampires in a quest to sacrifice the elders to summon La Magra, the blood god, and turn the world into an eternal feeding ground for his vampire horde.
The film's plot involves Blade searching for Frost and finding clues to his plan to overthrow the vampire ranks. His search eventually takes him to the vampire archives. The pages are protected by an incredibly obese vampire called Pearl and Blade tortures her with UV light until he finds out the details involved in Frost's plan. Deacon needs the souls of 12 elder vampires as well as Blade's blood to successfully perform the ritual.
The film's final act takes place at the Temple of Eternal Night where Frost has taken Blade to drain his blood and complete the ritual. Frost is able to summon La Magra, but Blade manages to defeat them both. However, in the world of Darkhold, Frost succeeds in unleashing La Magra's power which is known as the V-Wave. This is the vampiric energy force that changed the entire population into humans and vampires. The entire Earth is being divided amongst the most powerful vampires including Dracula, who controls all of Europe. A vampiric Wilson Fisk controls New York City and his obese figure is a call back to the record keeper Pearl in the Blade film.
While Blade is hunting vampires he has a run-in with another group that calls themselves the Last Avengers. This group consists of Prowler, Silver Sable and Citizen V who is actually Kurt Wagner. Wagner was Nightcrawler of the X-Men before the V-Wave turned him into a human. Blade goes on to kill Wagner in battle and tells him that the Earth no longer needs protectors, it needs a king. Blade goes on to declare war on the entire vampire world and make a bone-chilling statement that every single drop of blood in the world now belongs to him.
The biggest plot divergence from the Blade film and Darkhold: Blade has to do with La Magra. In the film, La Magra possesses Deacon Frost and Blade faces and defeats him in combat. When Frost sacrifices himself to summon La Magra in Darkhold it automatically triggers the V-Wave and turns the entire Earth into vampires and their food. This creates an even more ruthless version of the Daywalker that will hunt down not only vampires but Avengers as well.