The hit CBS comedy The Big Bang Theory will end its successful run at the end of its upcoming 12th season, which premieres next month.

Warner Bros. Television and Chuck Lorre Productions made the announcement this afternoon in a joint statement with CBS that read, in part, “We are forever grateful to our fans for their support of The Big Bang Theory during the past twelve seasons. We, along with the cast, writers and crew, are extremely appreciative of the show’s success and aim to deliver a final season, and series finale, that will bring The Big Bang Theory to an epic creative close.”

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The hit sitcom, which centers on pair of physicists, played by Johnny Galecki and Jim Parsons, and their socially awkward friends, premiered in 2007 on CBS to mixed reviews, but quickly grew into a ratings juggernaut and a critical darling. To date, The Big Bang Theory has been nominated for 52 Emmy Awards, and won 10 -- although it has yet to earn Outstanding Comedy Series.

With the conclusion of its 12th, and final, season in May 2019, The Big Bang Theory will have aired 279 episodes, breaking the record for the longest-running single-camera comedy in television history.

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Starring Johnny Galecki, Jim Parsons, Kaley Cuoco, Simon Helberg, Kunal Nayyar, Mayim Bialik and Melissa Rauch, The Big Bang Theory returns Monday, Sept. 24, at 8 p.m. ET/PT on CBS before moving to its regular night on Thursday, Sept. 27.