Many friends have become fan-favorite characters in TV shows, whether for their chemistry, humor, or contributions to the plot. However, not all best-friend duos are considered compatible and not all friendships start out on the best note. The most compatible best friends are the ones who support one another, can make each other laugh, and are loyal.

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Instead of breaking each other down or turning their back, these friends lift each other up. Some of the best TV friendships are the ones fans never thought would happen. There are many iconic, memorable, compatible, and fan-favorite TV friends.

10 Sheldon And Penny Were Unexpected

Big Bang Theory

Penny and Sheldon in The Big Bang Theory

Sheldon and Penny may seem like an odd duo, as they don't seem to get along. For most of The Big Bang Theory, they have their ups and downs, but they always overcome these obstacles. Sheldon and Penny are the opposite of one another, which serves to better them both.

Sheldon and Penny slowly develop a friendship over time and become rather compatible with one another. They begin to care for each other and start providing advice and insight when needed. Sheldon may go too far and Penny might be an airhead, but they give each other knowledge, perspective, and support throughout The Big Bang Theory.

9 Trevor And Sypha Have An Unbreakable Bond

Castlevania

Sypha and Trevor exchange banter in Castlevania

Trevor and Sypha are an odd duo, but they make it work. Over time, they develop an unbreakable bond that allows them to take on creatures of all kinds. They become so compatible that their fighting styles even look similar to one another.

Trevor and Sypha become in sync as they combine their strengths to defeat the creatures of the night in Castlevania. No matter what the world throws at them, they will defeat it together. Trevor and Sypha may not have gotten along in the beginning, but they were inseparable by the end.

8 Kim Possible And Ron Stoppable Are Polar Opposites

Kim Possible

Kim Possible and Ron Stoppable together in Kim Possible.

Kim and Ron have been friends for most of their life. Kim helps challenge Ron, while he helps to keep Kim grounded. High school can be a tough time for teenagers and to make it all the more difficult, the titular character of Kim Possible fights crime in her spare time.

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Kim wouldn't be able to handle her difficult life if it weren't for her best friend Ron helping her along the way. Ron may make mistakes and Kim might handle most of the combat, but they make a perfect team. The two can take on anything together, and they do just that throughout Kim Possible.

7 Wayne And Darry Spend All Their Time Together

Letterkenny

Wayne and Darry in LetterKenny

Wayne and Darry are two peas in a pod. Wayne may be the toughest guy in Letterkenny, but Darry is always the first one to back him up in a fight. Unlike other best-friend duos, Darry goes to Wayne's house just about every day. He even remembers to bring his own yogurt just in case Wayne doesn't have any.

Wayne and Darry share plenty of traditions with one another, like the "super-soft birthday parties." Given how much time the two spend together, it's no surprise that they are close, compatible friends who know everything about each other.

6 Joey And Chandler Are More Than Roommates

Friends

Joey and Chandler in Friends

Joey and Chandler are the most compatible duo in Friends. It was by chance that the two became roommates and started their long-lasting friendship. Their friendship only grows stronger throughout Friends, even after Chandler's betrayal when he kisses Joey's girlfriend.

Friends did a great job of showing how much they need each other during the few episodes where Joey had moved into his own apartment. This best-friend duo has become so compatible that they eventually rely on one another. Chandler even tells Monica that they'll need a room for Joey when they're looking to buy their new house.

5 Grace And Frankie Rely On Each Other

Grace And Frankie

Grace and Frankie relaxing in beach chairs while holding hands.

Grace and Frankie became best friends during a time when they needed each other the most. After getting divorced from their husbands, Grace and Frankie move into a beach house. After a short adjustment period, the two women become inseparable.

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Grace and Frankie follow each other and are always putting the other first, even if they don't realize it. They may be polar opposites, but opposites attract, and they are a compatible duo. Grace and Frankie give a new meaning to best friends as they refuse to let anything come between them.

4 Lorelai And Sookie Helped Each Other Achieve Their Dreams

Gilmore Girls

Sookie and Lorelai standing in their kitchen.

Lorelai and Sookie are quite the pair. During Gilmore Girls, this best friend duo endures some tough times and tackles just about everything together. They constantly rely on each other, offer useful advice, and help the other through difficult situations.

Their bond is strong and will get them through anything. Throughout Gilmore Girls, Lorelai and Sookie become an unstoppable duo, which leads to them both achieving their dreams. Lorelai and Sookie's goals and dreams would not have been as achievable without their friendship and support.

3 Jess And Cece Put Each Other First

New Girl

Jess and Cece stealing an appliance from a store.

Jess and Cece have been friends since middle school and have accompanied each other on numerous adventures. Like most friendships, they have their ups and downs, but they always come out on top. Despite their differences, Jess and Cece remain close and are always there for each other no matter what.

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Both Jess and Cece are always the first to defend, stand up, or help the other. Even when Jess's boyfriend knows something about Cece's relationship, Jess puts her friendship with Cece above her relationship with Nick to make sure that Cece is okay.

2 Veronica And Fiona Are Always There

Shameless

Veronica and Fiona enjoying coffee on their front steps.

Veronica and Fiona give the phrase "partners in crime" a whole new meaning. Throughout Shameless' 11 seasons, the pair have a stable friendship. Even when Fiona makes some poor life choices, Veronica is the only person defending her and trying to help her get better. They are neighbors by chance but best friends by choice.

Fiona and Veronica are always there to help the other's family. Life is tough in the South Side of Chicago, but Fiona and Veronica find solace in dancing and hanging out together. Like most friendships, Veronica and Fiona have their arguments, but it never seems to phase them for long.

1 Shaggy And Scooby-Doo Are Joined At The Hip

Scooby-Doo

Shaggy holding Scooby after he had been frightened.

Dogs may be considered man's best friend, but Shaggy and Scooby take their friendship to another level. They are one of the most compatible best friend duos, despite being part of different species. While the rest of Mystery Inc. is off solving the mystery, Shaggy and Scooby can be found in the kitchen making themselves a snack.

No matter how scared Scooby and Shaggy are, the two heroes never give up in Scooby-Doo. Ever since they were young, they have always had each other's backs, and that's never going to change.

NEXT: 10 Most Memorable TV Duos