The Marvel Cinematic Universe may be taking more of a step towards cosmic adventures once Infinity War has concluded, and Miles could fit right into that move. He's lived a more cosmic life than most teen superheroes can boast, from meeting the version of himself from his new universe, to working with the Avengers and Champions to stop two Earths from combining into a single planet.
Even before he moved from the Ultimate Universe to the MU-proper thanks to Secret Wars, Miles found himself dimension-hopping thanks to the first Spider-Men series, and a brief stint with the time-displaced X-Men. Any worries that Marvel might have about Miles not fitting with the direction planned for the MCU would ring hollow; after all, it was his simple act of kindness and giving Molecule Man a cheeseburger that allowed for Marvel's comics universe to be restored. His core of genuine goodness and empathy simply plays well against the backdrop of massively cosmic events.
Up until fairly recently, Miles was only a hero because Peter was dead and gone. Peter's death in the MCU makes things much more complicated and there's not much of a Spider-Man legacy for Miles to live up to. But it could also make things more interesting for Miles. What is he like without any trace of Peter's history hovering over him? He'd still be young and inexperienced, so Peter can show him the ropes upon his return, but it's a question worth posing regardless.
Another upside to this move would be that by including Miles now, Marvel and Sony wouldn't have to waste time finding a way to bring his character in later. Thus, once Holland's contract ends, they could shift the movie franchise to focus on Spider-Man: Miles Morales, or whatever they end up calling it, without missing a step. By doing with Miles what Civil War did with Black Panther, or Thor Ragnarok did with the Hulk, the stage would be set for Miles to go on to bigger and better things sooner than later.
We've seen Spider-Man interact with most of the big players of the MCU, so now it's time to see what he's like with someone in his own relative inner circle. Following his transfer to the main Marvel Comics universe, the solution was to make him the New York-based Spider-Man while Peter's Spidey went on globetrotting adventures. Holland's Homecoming sequel already sounds like it'll have Peter travel the world, and New York will always need a Spider-Man. If nothing else, this gives Sony and Marvel both of their cakes while allowing them to eat them at the same time. The studios get a Peter Parker who goes international, and we get the Miles Morales films fans have wanted since the character first showed up.
Directed by Joe and Anthony Russo, Avengers: Infinity War stars Robert Downey Jr., Chris Evans, Chris Hemsworth, Mark Ruffalo, Jeremy Renner, Scarlett Johansson, Anthony Mackie, Paul Rudd, Elizabeth Olsen, Tom Holland, Benedict Cumberbatch, Chadwick Boseman, Chris Pratt, Zoe Saldana, Dave Bautista, Bradley Cooper, Vin Diesel, Tom Hiddleston, and Josh Brolin. The film is playing in theaters in everywhere.